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First received: November 11, 2022

Clinical Trial: Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Study Status: Completed

Recruit Status: Completed

Condition: Locally Advanced Rectal Carcinoma

Study Type: Interventional


Official Title: Prospective Phase II Study of Hypofractionated Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Brief Summary: The goal of this clinical trial is to investigate total neoadjuvant therapy (TNT) using short course radiation therapy (SCRT) followed by full course of chemotherapy then surgery in locally advanced rectal cancer. The main questions it aims to answer are:Is total neoadjuvant treatment in this design safe & tolerable?Impact of this design on treatment related outcomes in terms of pathological and clinical responses.

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