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Guizhi-Shaoyao-Zhimu decoction alleviates gastrointestinal acute graft-vs.-host disease and suppresses FGF2/PI3K/Akt signaling: insights from network pharmacology, WGCNA, molecular docking, and animal experiment

Abstract: To evaluate the potential preventive effects of Guizhi-Shaoyao-Zhimu Decoction (GSZD) on gastrointestinal acute graft-vs.-host disease (GI-aGVHD) and explore its…

Date: 2026-10-23

Transcriptomic analysis identifies STAT1 as a potential key transcriptional regulator of T-cell dysfunction in AIHA

Abstract: Autoimmune hemolytic anemia (AIHA) is characterized by antibody-mediated red blood cell destruction. T-cell dysfunction is implicated in its pathogenesis, but the…

Date: 2026-10-23

Neutrophil–microglia communication through the C3–C3aR1 axis contributes to secondary neuroinflammation after traumatic brain injury

Abstract: Traumatic brain injury (TBI) triggers a rapidly evolving neuroinflammatory response that contributes to secondary brain injury. Although infiltrating leukocytes and…

Date: 2026-10-23

Co-creating the EndoWatch - a smart wearable device for the management of hypothalamic dysfunction in pediatric brain tumor survivors: a pilot study

Abstract: Hypothalamic dysfunction (HD) after treatment for a pediatric (supra)sellar tumor severely affects quality of life of patients, as well as their parents and families.…

Date: 2026-10-23

Association between latent profiles of disease risk perception and health-promoting behaviors among adult offspring of patients with type 2 diabetes mellitus: a cross-sectional study

Abstract: To identify latent profiles of disease risk perception among adult offspring of patients with type 2 diabetes mellitus and examine their associations with…

Date: 2026-10-23

Association of the triglyceride–glucose index with the severity of lower extremity arterial disease across glucose metabolic states: a single-center cross-sectional study of 656 patients with angiographically confirmed disease

Abstract: To examine the cross-sectional association between the triglyceride–glucose (TyG) index and the severity of lower extremity arterial disease (LEAD) in hospitalized…

Date: 2026-10-23

Circulating NET-associated parameters across chronic inflammatory skin diseases: a comparative study

Abstract: Neutrophil extracellular traps (NETs) are important components of innate immunity and may contribute to immune dysregulation in chronic inflammatory skin diseases.…

Date: 2026-10-23

Death by neurologic criteria and organ donation in German pediatric intensive care units—data from the PIA network

Abstract: Each year, between 250 and 300 children are listed for organ transplantation in Germany, while approximately 30 children donate organs. Despite identified barriers to…

Date: 2026-10-23

Physicochemical characteristics, antioxidant capacity, and oxidative stress profiles of dairy and plant-based milks: a comparative multivariate analysis

Abstract: The increasing consumption of plant-based milk (PBM) alternatives has intensified interest in their physicochemical composition and functional properties relative to…

Date: 2026-10-23

The development and validation of a questionnaire to assess female athletes’ and coaches’ knowledge about hormonal contraception

Abstract: In this study, a hormonal contraception knowledge questionnaire (HCKQ) for female athletes and coaches was developed and validated. An initial 17-item questionnaire…

Date: 2026-10-23