Clinical Trial: Comparison Between the Effects of High Doses Statin on Ventricular Remodeling in STEMI Patients
Study Status: COMPLETED
Recruit Status: COMPLETED
Condition: ST-segment Elevation Myocardial Infarction
Study Type: INTERVENTIONAL
Official Title: Comparative Study Between the Effects of High Doses Rosuvastatin and Atorvastatin on Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction
Brief Summary:
STEMI is a serious type of coronary heart disease, which is a major cause of disability and death.Morphologically the key feature of remodeling is myocyte hypertrophy, myocyte loss from necrosis or apoptosis, as well as interstitial cell growth especially fibroblast proliferation leading to myocardial fibrosis .Elevated serum LDL-cholesterol concentrations play a proatherogenic role by stimulating inflammation and oxidative processes.Statins have been documented to retard fibrosis and ventricular hypertrophy by…
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