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First received: September 08, 2022

Clinical Trial: Defining Neurobiological Links Between Substance Use and Mental Illness

Study Status: Completed

Recruit Status: RECRUITING

Condition: Major Depressive Disorder

Study Type: INTERVENTIONAL


Official Title: Defining Neurobiological Links Between Substance Use and Mental Illness

Brief Summary: Background:Nicotine dependence leads to about 480,000 deaths every year in the United States.People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.They have greater withdrawal symptoms and are more likely to relapse after quitting compared with smokers without MDD.More research is needed on how nicotine affects brain function in those with MDD.Objective:To understand how nicotine affects symptoms of depression and related brain…

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