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First received: October 17, 2022

Clinical Trial: High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)

Study Status: Completed

Recruit Status: RECRUITING

Condition: Opioid Use Disorder

Study Type: INTERVENTIONAL


Official Title: Safety and Efficacy of High Dose Buprenorphine Induction in Fentanyl Positive Emergency Department Patients

Brief Summary: This project, involving two distinct clinical trials, tests whether induction to a higher than currently recommended buprenorphine (BUP) induction dose is safe and can improve the proportion of patients who engage in comprehensive addiction services within 7-day of induction.Trial 1 is a head-to-head comparison of the safety, tolerability and feasibility of high dose BUP induction (32 mg).The study involves two cohorts, (1) a 12mg cohort (standard) to determine baseline data and (2) a 32 mg (high dose) cohort.If…

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