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First received: December 06, 2022

Clinical Trial: Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Hepatic Encephalopathy

Study Type: INTERVENTIONAL


Official Title: Intravenous Branched-chain Amino Acids for Overt Hepatic Encephalopathy in Patients With Acute on Chronic Liver Failure - A Multi-centric Double-blind Randomized Controlled Trial

Brief Summary: This multi-centric study analyses the effect of intravenous branched-chain amino acids (BCAA) on overt HE in patients with ACLF.The investigators aim to study the efficacy of combining intravenous BCAA with lactulose versus lactulose alone, ammonia measures, endotoxin, metabolomics, and cerebral edema in the medical management of overt HE in patients with ACLF.The study will also access the impact on overall survival and improvement in the grade of HE.

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