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Course: Ominous Electrocardiographic Abnormalities in a Patient With Hepatocellular Carcinoma

CME Credits: 1.00

Released: 2022-04-25

A patient in their early 60s presented to the emergency department with 1 week of progressive weakness, myalgia, dyspnea, and ptosis. The patient’s medical history was significant for hepatocellular carcinoma, for which the patient had received radical surgery followed by an initial dose of camrelizumab 1 month before presentation. Vital signs on admission noted a blood pressure of 150/90 mm Hg, respiratory rate of 27 breaths per minute, heart rate of 108 beats per minute, and oxygen saturation of 92% on room air. Investigation revealed a creatinine phosphokinase level of 8156 U/L (reference range, <190 U/L), troponin I level of 1.47 ng/mL (reference range, <0.01 ng/mL; to convert to ?g/L, multiply by 1), brain natriuretic peptide level of 267.3 pg/mL (reference range, <300 pg/mL), and a positive test result for acetylcholine receptor antibodies. Echocardiogram results showed a preserved left ventricular ejection fraction without wall-motion abnormalities. A routine electrocardiogram (ECG) performed 1 month earlier yielded normal results. The ECG obtained on this admission is shown in the , A.


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