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Course: Yellow Urticaria

CME Credits: 1.00

Released: 2022-04-06

A man in his 70s presented to the hospital with dark urine in the setting of increased acetaminophen use. Hours after receiving a computed tomography scan with iodine-based contrast, he developed a pruritic rash. A physical examination revealed scleral icterus, jaundice, and well-circumscribed, bright yellow papules and plaques on his lateral abdomen (). Laboratory findings included an alkaline phosphatase level of 903 U/L (to convert to ?kat/L, multiply by 0.0167), total bilirubin level of 13.3 mg/dL (to convert to ?mol/L, multiply by 17.104), direct bilirubin level of 11.6 mg/dL, alanine transaminase level of 124 U/L, and aspartate transaminase level of 145 U/L. A biopsy of the liver revealed findings consistent with drug-induced liver injury. His rash responded to treatment with antihistamines, and his transaminase levels improved with cessation of acetaminophen use.


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