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Course: Giant Conjunctival Carcinoma in an Adult Man

CME Credits: 1.00

Released: 2022-03-17

A 67-year-old man presented with a giant red and yellow tumor growing from the lower fornix of the right eye for 1 year (, A). Visual acuity was hand motion OD owing to the tumor location obstructing the visual axis. Under general anesthesia, the macroscopically visible tumor was resected. After staining with hematoxylin-eosin, histopathologic analysis of the specimen revealed an inflammatory and desmoplastic stroma, epithelial fingerlike projections, single-cell keratinization, and atypical keratinocytes with mitotic figures consistent with an abortive keratinizing squamous cell carcinoma of the conjunctiva (, B). To distinguish keratinizing squamous cell carcinoma from pseudoepitheliomatous hyperplasia, multiple histologic sections were examined. Further analysis revealed residual tumor cells at the surgical margin (R1 classification, microscopic infiltration of the tumor margin), and there was no evidence for orbital involvement on magnetic resonance imaging. As a result, topical chemotherapy with 2 cycles of mitomycin C, 0.04%, was administered. Postoperative best-corrected visual acuity improved to 20/30 OD.


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