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Course: Generalized Micropapular Eruption in a Teenager

CME Credits: 1.00

Released: 2022-03-02

A teenaged boy presented to the outpatient clinic with a 1-year history of asymptomatic cutaneous lesions on the face that had progressively spread to the trunk and extremities. He also had asthenia and mild intermittent arthralgias. Physical examination revealed multiple millimetric erythematous to hyperpigmented monomorphic keratotic papules involving the head, trunk, and extremities. Symmetric annular brown erythematous plaques on the cheeks and temples were also seen. There were no vesicles or pustules (, A and B). Laboratory investigations revealed a normal white blood cell count, mild anemia (hemoglobin level, 11.3 g/dL; normal level 12.50-15.50 g/dL; to convert to g/L, multiply by 10.0), hypocomplementemia, and moderate proteinuria. Autoimmune serology results showed raised levels of antinuclear antibodies (>1:160), anti-Smith antibodies, SSA/Ro antibodies, SSB/La antibodies, and anti-U1RNP antibodies. Anti-dsDNA antibodies, lupus anticoagulant, rheumatoid factor, IgG and IgM anticardiolipin antibody, and anti--2 glycoprotein 1 antibody results were negative. A biopsy specimen obtained from an erythematous papule on the trunk and stained with hematoxylin-eosin is shown in the , C and D.


Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.


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