Course: Decreased Vision and Eye Pain in a 55-Year-Old Man
CME Credits: 1.00
Released: 2022-01-20
A 55-year-old man with advanced primary open-angle glaucoma presented with 1 day of decreased vision and eye pain. He had undergone trabeculectomy and 5-fluorouracil injection 1 month prior. On initial examination, his visual acuity was 20/25. He had diffuse conjunctival hyperemia without bleb purulence or leakage and more than 50 cells per high-power field of a 1?×-1-mm area of light on slitlamp biomicroscopy. He was treated for blebitis with topical fortified antibiotics but subsequently developed vitritis. He underwent vitreous tap and injection of vancomycin and amikacin followed by pars plana vitrectomy with bleb revision. Separate vitreous samples from each procedure were sent for Gram stain and bacterial and fungal culture on chocolate and Sabouraud agar with no growth. His eye pain worsened significantly, and ultrasound biomicroscopy showed scleral thickening (A). Lab workup for autoimmune scleritis including tests for rheumatoid factor, antinuclear antibodies, and antineutrophil cytoplasmic antibodies was negative. He was admitted to the hospital and started intravenous vancomycin and piperacillin-tazobactam treatment. His vision continued to decline to counting fingers because of the development of a dense cataract with retrolenticular plaque (B).
Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
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