Clinical Documents

To edit the draft, click on the text box below.

×

Draft a comprehensive differential diagnosis for acute substernal chest pain in a 45-year-old male with hypertension and hyperlipidemia, diaphoresis, exertional onset, and normal initial ECG/troponin; include life-threatening causes first, key distinguishing features, and immediate diagnostic next steps.

Draft a detailed differential diagnosis for new-onset unilateral throbbing headache with visual aura and brief monocular vision loss in a 32-year-old female on oral contraceptives; include red-flag symptoms, stroke/TIA considerations, and recommended initial workup.

Draft an assessment and plan for stage-2 hypertension (BP 162/98) in an obese 52-year-old with suspected obstructive sleep apnea; include ASCVD risk estimate, lifestyle prescriptions, first-line pharmacotherapy with drug/dose/targets, baseline labs/monitoring, and 4–6 week follow-up.

Draft an assessment and plan for type 2 diabetes follow-up with A1c 9.2% on metformin 1,000 mg BID and eGFR 65; compare adding a GLP-1 receptor agonist vs an SGLT2 inhibitor, address weight loss goals, hypoglycemia education, vaccinations, and micro/macrovascular screening.

Draft a history and physical for a patient presenting with chest pain, including HPI using OLDCARTS, pertinent ROS, PMH/meds/allergies, FH/SH, focused cardiac/pulmonary exam, initial labs and imaging orders, prioritized differential, HEART score risk stratification, and early management.

Draft a history and physical for a new patient with progressive exertional dyspnea, orthopnea, and bilateral leg edema; include differential (heart failure, COPD, PE, anemia, renal disease), targeted exam maneuvers, and first-line diagnostics and management.

Draft a progress note for COPD follow-up two weeks after an acute exacerbation treated with prednisone and antibiotics; include symptom trajectory, CAT score (if available), inhaler technique/adherence, oxygen needs, spirometry plan, smoking cessation counseling, and return precautions.

Draft a progress note for post-operative day 2 after total knee arthroplasty; include pain control strategy, DVT prophylaxis, PT/OT milestones, wound status, bowel/urinary function, labs/vitals review, complications screening, and discharge readiness.

Draft a discharge summary for community-acquired pneumonia admission; include admission/discharge dates, presenting symptoms, radiology/labs, pathogen if identified, inpatient therapies and response, discharge medications with durations, pending tests, follow-up appointments, and return precautions.

Draft a discharge summary for myocardial infarction managed with PCI and drug-eluting stent placement; include cath findings, complications, inpatient course, discharge medications (DAPT, statin, beta-blocker, ACEi/ARB), cardiac rehab referral, and follow-up plan.

Draft discharge instructions for a patient hospitalized with acute decompensated heart failure; include daily weights, sodium and fluid restriction amounts, medication list with dosing, signs of worsening heart failure, follow-up appointments, and lab monitoring plan.

Draft discharge instructions for an asthma exacerbation; include controller and reliever regimen, steroid taper schedule, spacer technique, trigger avoidance, a written asthma action plan, return precautions, and follow-up timing.

Draft a patient handout on managing high blood pressure in plain language; explain what BP numbers mean, key lifestyle steps (DASH diet, sodium limits, alcohol moderation), home BP monitoring instructions, medication adherence tips, and when to call the doctor.

Draft a patient handout for type 2 diabetes education in plain language; cover A1c goals, the plate method, physical activity targets, self-monitoring of blood glucose, hypoglycemia signs and the 15-15 rule, foot care basics, and a vaccination checklist.

Draft a summary of the latest CDC and WHO guidelines for managing community-acquired pneumonia in adults, including empiric antibiotic choices, duration of therapy, and follow-up recommendations.

Draft a plain-language overview of the ADA and AACE guidelines for diabetes management, focusing on A1c goals, weight management, and the use of GLP-1 receptor agonists and SGLT2 inhibitors.

Draft a summary of the 2024 USPSTF breast cancer screening recommendations, including updated screening intervals, risk-based approaches, and the role of MRI for high-risk patients.

Draft a concise summary of NCCN guidelines for melanoma management, including staging, surgical margins, adjuvant therapy, and checkpoint inhibitor recommendations.

Draft treatment alternatives for community-acquired MRSA skin infections in patients allergic to sulfa drugs; include oral and IV options, dosing, and duration.

Draft treatment alternatives for patients with type 2 diabetes who are unable to tolerate GLP-1 receptor agonists due to nausea; include medication substitutions and lifestyle recommendations.

Draft a summary of options for treating refractory depression, comparing ketamine infusions, transcranial magnetic stimulation (TMS), and electroconvulsive therapy (ECT).

Draft treatment options for advanced prostate cancer, including hormonal therapy, radiopharmaceuticals, and novel androgen receptor pathway inhibitors.

Draft a summary of recent research on mRNA vaccine technology beyond COVID-19, including applications in oncology and autoimmune disease prevention.

Draft an easy-to-understand overview of long COVID research, summarizing major symptoms, hypothesized mechanisms, and emerging treatment approaches.

Draft a summary of current research on Alzheimer’s disease biomarkers, including amyloid and tau imaging, and discuss how they influence diagnosis and trial design.

Draft an explanation of the interaction between warfarin and antibiotics such as ciprofloxacin or TMP-SMX, including INR effects and management recommendations.

Draft a summary evaluating drug interactions for patients taking Paxlovid and common cardiovascular drugs; include mechanism and recommended dose adjustments.

Draft a summary of the common and serious side effects of semaglutide, including GI intolerance, gallbladder disease, and thyroid-related warnings.

Draft an overview of potential side effects associated with long-term corticosteroid use, including osteoporosis, glucose intolerance, and adrenal suppression.

Draft a summary of essential lab tests to order in suspected acute pancreatitis, including amylase, lipase, liver enzymes, and metabolic panels, with interpretation guidance.

Draft laboratory workup recommendations for suspected hypothyroidism, including TSH, free T4, thyroid antibodies, and when to consider secondary causes.

Draft an explanation of which labs should be monitored in patients receiving methotrexate therapy, including CBC, LFTs, renal function, and frequency of monitoring.

why choose us

Edit Geo

×

300×250 Ad Slot

Research Article: Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy

Date Published: 2025-12-15

Abstract:
As a complex and persistent inflammatory bowel disease, the onset and progression of ulcerative colitis (UC) are closely associated with intestinal microbiota dysbiosis, host metabolic imbalance, and impaired intestinal barrier function. The traditional Chinese medicine Panax notoginseng (Sanqi) possesses multiple therapeutic properties, among which its anti-inflammatory effect is particularly remarkable. However, the specific molecular pathways through which Panax notoginseng exerts its anti-UC effects have not been fully elucidated. This study aims to clarify the efficacy and molecular mechanisms of Panax notoginseng extract in a mouse model of UC. A colitis model was established by inducing UC in ICR mice using dextran sulfate sodium (DSS). The experimental animals were divided into four groups: normal control group (CON), normal administration group (CONSQ), DSS-induced model group (DSS), and DSS-induced administration group (DSSSQ). The CONSQ and DSSSQ groups received oral gavage of 200 mg/kg Panax notoginseng extract. The evaluation indicators included the disease activity index, histopathological examination of colon tissue, expression of key intestinal barrier proteins, analysis of intestinal microbiota structure, and metabolomic testing of fecal samples. Treatment with Panax notoginseng extract repaired the damaged intestinal barrier, as evidenced by increased expression levels of Claudin-1, Occludin, ZO-1, and MUC-2 proteins. Simultaneously, the extract favorably modulated the structure of the intestinal microbiota, specifically by increasing the Firmicutes/Bacteroidetes ratio and enriching probiotic genera (such as Bifidobacterium and Lactobacillus). Furthermore, the extract significantly reduced the levels of characteristic metabolites (such as LysoPI and Etamiphylline). Correlation analysis based on multi-omics data revealed an interactive regulatory network centered on the intestinal microbiota, host metabolites, and intestinal barrier integrity, indicating that Panax notoginseng extract alleviates the pathological process of UC through a multi-target, synergistic approach. The results of this study demonstrate that Panax notoginseng extract exerts its therapeutic effects on UC by repairing the intestinal barrier, modulating the composition of the intestinal microbiota, and influencing the host metabolic profile. Multi-omics correlation analysis further revealed the central role of the microbiota–metabolite–barrier axis in the anti-UC effects of Panax notoginseng , providing strong evidence for its multi-target synergistic mechanism. These findings lay the foundation for a deeper understanding of the pharmacological mechanisms of Panax notoginseng in UC treatment and support its further development as a potential therapeutic agent for UC.

Introduction:
As a complex and persistent inflammatory bowel disease, the onset and progression of ulcerative colitis (UC) are closely associated with intestinal microbiota dysbiosis, host metabolic imbalance, and impaired intestinal barrier function. The traditional Chinese medicine Panax notoginseng (Sanqi) possesses multiple therapeutic properties, among which its anti-inflammatory effect is particularly remarkable. However, the specific molecular pathways through which Panax notoginseng exerts its anti-UC effects have not…

Read more

300×250 Ad Slot

×
Chat & Ask Questions Career Openings Medical Doctors Check on Drug
Interactions Latest Health News
by WebHealthNetwork Get CME Credits Latest Clinical Trials Latest Research Articles Clinical Documents Update Profile

News

Chat

HCP Tools

Careers

Update Profile