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Research Article: Erxiekang emplastra as adjunctive therapy for acute gastroenteritis in children: a single-center retrospective cohort study

Date Published: 2026-06-11

Abstract:
Standard treatments for pediatric acute gastroenteritis (AGE) have critical limitations in symptom control and medication adherence among young children. This study evaluated the efficacy and safety of Erxiekang Emplastra as adjunctive therapy for AGE in children aged 1 to 14 years. This single-center retrospective cohort study reviewed electronic medical records of children hospitalized with AGE between January 2024 and March 2025. Eligible patients were categorized into an exposed group receiving Erxiekang Emplastra plus standard therapy and an unexposed group receiving standard therapy alone. The primary outcome was diarrhea duration; secondary outcomes included the 3-day Modified Vesikari Scale (MVS) and treatment-related adverse events. Multivariable linear regression was conducted to quantify the independent therapeutic benefits of the Erxiekang Emplastra. A total of 1,089 eligible patients were included, with 417 in the exposed group and 672 in the unexposed group. The exposed group had significantly shorter diarrhea duration (3.83 vs. 4.92 days, p <?0.01) and lower 3-day MVS (2.90 vs. 4.51, p <?0.01). Adjunctive Erxiekang Emplastra was independently associated with reduced diarrhea duration ( ? =?–0.38, p <?0.01; R 2 =?0.19) and lower 3-day MVS ( ? =?–0.44, p <?0.01; R 2 =?0.22). Only 1.44% of patients developed mild transient local reactions, with no severe adverse events reported. Erxiekang Emplastra showed favorable tolerability in this pediatric AGE cohort, and its adjunctive use was independently associated with shortened diarrhea duration and reduced disease severity. Large-scale, multicenter, prospective randomized controlled trials are warranted to confirm the efficacy and safety of this intervention.

Introduction:
Standard treatments for pediatric acute gastroenteritis (AGE) have critical limitations in symptom control and medication adherence among young children. This study evaluated the efficacy and safety of Erxiekang Emplastra as adjunctive therapy for AGE in children aged 1 to 14 years.

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