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Research Article: Endometrial thickness is not a risk factor for hypertensive disorders of pregnancy after IVF treatment in women with male-factor infertility

Date Published: 2026-07-17

Abstract:
The relationship between endometrial thickness and adverse pregnancy outcomes has garnered significant attention from researchers. The aim of this study was to investigates whether endometrial thickness (EMT) is a risk factor for hypertensive disorders of pregnancy (HDP) in women undergoing in vitro fertilization (IVF) due to male-factor infertility. This single center retrospective cohort study included 2,536 women aged 20–40 years with male-factor infertility who underwent their first frozen-thawed embryo transfer (FET) and had a singleton live birth. Endometrial thickness was measured via transvaginal ultrasound on the day of embryo transfer, and patients were divided into three groups: ?8 mm, 8–14 mm, and ?14 mm. The primary outcome was the incidence of HDP. The overall HDP rate was 3.67%, with no significant difference across EMT groups: 3.97% in the ? 8 mm group, 3.74% in the 8–14 mm group, and 3.03% in the ? 14 mm group (p=0.760). Older maternal age and higher BMI were significant risk factors for HDP [maternal age (OR 1.10, 95% CI 1.05-1.16, p=0.000) and BMI ? 24.0 Kg/m² (OR 2.40, 95% CI 1.10-5.25, p=0.028)], while EMT was not associated with HDP risk. Endometrial thickness was not a significant risk factor for HDP in women with male-factor infertility undergoing their first FET.

Introduction:
The relationship between endometrial thickness and adverse pregnancy outcomes has garnered significant attention from researchers. The aim of this study was to investigates whether endometrial thickness (EMT) is a risk factor for hypertensive disorders of pregnancy (HDP) in women undergoing in vitro fertilization (IVF) due to male-factor infertility.

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