why choose us

300×250 Ad Slot

Research Article: Impact of levonorgestrel-releasing intrauterine device on amenorrhea rates after endometrial resection or ablation in women with abnormal uterine bleeding

Date Published: 2026-04-28

Abstract:
To evaluate the impact of adjunctive levonorgestrel-releasing intrauterine device (LNG-IUD) placement on amenorrhea rates and hysterectomy risk following endometrial resection or ablation in women with abnormal uterine bleeding (AUB). A retrospective cohort study was conducted involving 385 premenopausal women undergoing surgery for AUB. Patients were divided into surgery-only ( n =?238) and surgery + LNG-IUD ( n =?147) groups. Amenorrhea and hysterectomy rates were assessed at 12?months postoperatively. Multivariate logistic regression analyses were performed to examine the association of adjunctive LNG-IUD use with the risks of amenorrhea and hysterectomy, adjusting for potential confounders. The surgery + LNG-IUD group demonstrated a significantly higher amenorrhea rate compared to the surgery-only group (61.2% vs. 24.4%, p <?0.01) and a lower hysterectomy rate (10.2% vs. 20.2%, p <?0.01). Multivariate logistic regression showed that adjunctive LNG-IUD use independently increased the odds of amenorrhea (adjusted OR?=?4.89, 95% CI: 3.07–7.78, p <?0.01) and decreased the risk of hysterectomy (adjusted OR?=?0.45, 95% CI: 0.24–0.85, p =?0.01). Adjunctive LNG-IUD placement significantly improves amenorrhea rates and reduces the risk of hysterectomy after endometrial surgery in women with AUB.

Introduction:
Abnormal uterine bleeding (AUB) is a common gynecologic complaint, affecting up to 30% of reproductive-aged women globally and accounting for nearly one-third of outpatient gynecology visits ( 1 , 2 ). AUB significantly compromises quality of life, contributes to iron-deficiency anemia, and imposes a substantial healthcare burden ( 3 , 4 ). In the United States alone, the estimated annual direct costs associated with AUB range from $1 to $1.55 billion, with indirect costs reaching $12 to $36 billion, largely due…

Read more

300×250 Ad Slot