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Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism

Abstract: Background: As a core personality trait closely linked to mental health outcomes, psychoticism warrants particular attention in adolescent populations. The association…

Date: 2025-03-24

Comprehensive multiomics analysis identifies PYCARD as a key pyroptosis-related gene in osteoarthritis synovial macrophages

Abstract: Background: Osteoarthritis (OA) is a chronic joint disease that significantly impairs quality of life. Synovitis plays a pivotal role in OA progression, and pyroptosis,…

Date: 2025-03-24

Telitacicept as an alternative to non-steroidal immunosuppressive therapies in the treatment of myasthenia gravis: a study on clinical efficacy and steroid-sparing effect

Abstract: Introduction: Myasthenia Gravis (MG) is an autoimmune disorder characterized by impaired neuromuscular junction (NMJ) transmission. Current treatments for MG include…

Date: 2025-03-24

Serum miRNA-186-3P and miRNA-382-3P constitute a novel Diagnostic miRNA signature for palindromic rheumatism

Abstract: Background: Palindromic rheumatism (PR) is a unique disease characterized by the intermittent inflammation of different joints that may progress to a variety of…

Date: 2025-03-24

Efficacy and safety of simultaneous integrated boost intensity-modulated radiotherapy combined with temozolomide for the postoperative chemotherapy treatment of multifocal high-grade glioma

Abstract: Background: The multifocal manifestation of high-grade glioma is a rare disease with an unfavorable prognosis. The pathogenesis of multifocal gliomas and…

Date: 2025-03-24

Quantitative correlation between carotid or lower limb atherosclerosis and coronary heart disease: a retrospective observational study

Abstract: Background: Early diagnosis and intervention are key for the treatment of coronary heart disease (CHD). Ultrasound is used to assess risk stratification in patients with…

Date: 2025-03-24

A viral infection prediction model for patients with r/r B-cell malignancies after CAR-T therapy: a retrospective analysis

Abstract: Background: Chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgkin lymphoma…

Date: 2025-03-21

Chloride channel-3 regulates sodium-iodide symporter expression and localization in the thyroids of mice on a high-iodide diet

Abstract: Introduction: Certain chloride channels and H+/Cl? antiporters, such as chloride channel 3 (ClC-3), are expressed at the apical pole of thyrocytes, facilitating iodide…

Date: 2025-03-21

Glypican-4 trajectory predicts the risk of gestational diabetes mellitus and the requirement for insulin therapy during pregnancy

Abstract: Background: Gestational diabetes mellitus (GDM), characterized by the onset of glucose intolerance during pregnancy, results in a series of complications for maternal…

Date: 2025-03-21

Circadian rhythm related genes identified through tumorigenesis and immune infiltration-guided strategies as predictors of prognosis, immunotherapy response, and candidate drugs in skin cutaneous malignant melanoma

Abstract: Background: Skin cutaneous malignant melanoma (SKCM) is among the most aggressive forms of skin cancer, notorious for its rapid progression and poor prognosis under late…

Date: 2025-03-21