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Single-cell transcriptomic profiling of bronchial lymph nodes reveals mechanisms of PRRSV escape from host adaptive immunity

Abstract: Porcine reproductive and respiratory syndrome (PRRS), caused by porcine reproductive and respiratory syndrome virus (PRRSV), is characterized by impaired adaptive immune…

Date: 2026-07-15

Deoxyguanosine kinase deficiency couples purine metabolism to innate immune activation and lipid accumulation in hepatocytes

Abstract: Mitochondrial DNA depletion syndromes (MDS) caused by deoxyguanosine kinase (DGUOK) deficiency are classically attributed to impaired mitochondrial DNA (mtDNA)…

Date: 2026-07-15

Inflammatory indexes as prognostic biomarkers in advanced triple negative breast cancer patients

Abstract: The immune system is known to be involved in the microenvironment of triple negative breast cancer (TNBC). Immune ratios such as the neutrophil-to-lymphocyte ratio…

Date: 2026-07-15

Prognostic significance of extracapsular extension in patients with non-small cell lung cancer following neoadjuvant chemoimmunotherapy: a retrospective cohort study

Abstract: Non-small cell lung cancer (NSCLC) is a leading cause of oncology-related mortality. Although neoadjuvant chemoimmunotherapy (NCIT) improves pathologic response, disease…

Date: 2026-07-15

Consolidative versus salvage stereotactic ablative radiotherapy to the primary lung tumor in stage IV non–small cell lung cancer

Abstract: The optimal timing of stereotactic ablative radiotherapy (SABR) to the primary lung tumor—whether delivered as consolidative therapy or as salvage therapy —remains…

Date: 2026-07-15

Sequential tislelizumab plus bronchial arterial chemoembolization and systemic chemotherapy in advanced NSCLC with bulky tumors: efficacy and safety

Abstract: Bulky tumor (T ? 50 mm) significantly compromises treatment outcomes in advanced non-small cell lung cancer (NSCLC) due to excessive tumor burden. Bronchial arterial…

Date: 2026-07-15

Evaluation of an interpretable deep-learning model for the automated plan review of intensity-modulated radiation therapy

Abstract: Intensity-modulated radiation therapy (IMRT) is a treatment modality for delivering a higher radiation dose to the target using multiple radiation beams from various…

Date: 2026-07-15

Toxicological impact of benzo[a]pyrene on esophageal cancer: an integrated analysis via network toxicology, machine learning, and molecular docking

Abstract: To investigate the mechanisms underlying benzo[a]pyrene-induced esophageal cancer (EC), and to screen and identify the key targets and biomarkers associated with…

Date: 2026-07-15

Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma

Abstract: Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive forms of solid tumors, is characterized by extensive fibrosis and an immunosuppressive tumor…

Date: 2026-07-15

Association of the C-reactive protein-triglyceride glucose index with microvascular obstruction and long-term prognosis in patients with acute myocardial infarction: a CMR-based study

Abstract: The clinical benefits of percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) are frequently compromised by the occurrence of microvascular…

Date: 2026-07-15