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Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis

Abstract: To investigate the therapeutic efficacy of Modified Meridian-Guided Acupoint Pressing (MMGAP) in lumbar facet joint osteoarthritis (LFJ OA) and to explore its underlying…

Date: 2026-07-08

TyG index is associated with colorectal adenomatous polyps and genetically linked to colon polyps: a cross-sectional and Mendelian randomization study

Abstract: The triglyceride-glucose (TyG) index, a simple and validated surrogate marker of insulin resistance, may be clinically relevant to colorectal polyp development because…

Date: 2026-07-08

Post-endoscopy gastric cancer in Latin America: a multicentre cohort study from Colombia

Abstract: Post-endoscopy gastric cancer (PEGC), defined as gastric cancer diagnosed after a negative upper gastrointestinal endoscopy, is considered a key indicator of endoscopic…

Date: 2026-07-08

A preliminary study on brain functional magnetic resonance imaging in migraine patients with visual aura using visual stimulation

Abstract: Migraine is characterized by high prevalence, recurrent attacks, and poor response to pharmacological interventions, which can severely impair patients’ quality of life.…

Date: 2026-07-08

Stage-specific digital health technology biomarkers enhance diagnostic and early progression detection in Parkinson’s disease

Abstract: Digital health technology measurements show promise as objective biomarkers in Parkinson’s disease. However, their sensitivity and consistency across early disease…

Date: 2026-07-08

G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids

Abstract: Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) has been shown to bind cytosolic nucleic acid sensors including retinoic acid-inducible gene I (RIG-I)…

Date: 2026-07-08

Insulin potentiates lipopolysaccharide-induced IL-6 expression through epigenetic remodeling in adipocytes: in vitro and in vivo mechanistic study

Abstract: Interleukin-6 (IL-6) is a central mediator of chronic low-grade inflammation associated with metabolic disease. Because obesity is characterized by elevated circulating…

Date: 2026-07-08

Increased phenotypic and functional stability of human allospecific induced Tregs is associated with Vitamin C-mediated FOXP3 TSDR demethylation

Abstract: While numerous preclinical models emphasize the therapeutic promise of in vitro -induced Tregs (iTregs) for managing inflammatory diseases and promoting tolerance, their…

Date: 2026-07-08

Integrated approach of guided honest disclosure and palliative care for advanced lung cancer: impacts on emotional distress, symptom burden, and patient satisfaction

Abstract: To explore the feasibility and clinical value of a comprehensive nursing model that integrates guided open communication strategies with the philosophy of palliative…

Date: 2026-07-08

Utilization of immunotherapy as a neoadjuvant treatment in liver transplant recipients with hepatobiliary carcinoma

Abstract: Hepatobiliary carcinoma (HBC) ranks as the sixth most prevalent cancer worldwide. Orthotopic liver transplantation (OLT) has emerged as a highly effective treatment…

Date: 2026-07-08