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Plasma cell-free DNA genome-wide methylation profiling enables detection and activity assessment in systemic lupus erythematosus

Abstract: Cell-free DNA (cfDNA) has emerged as a promising non-invasive biomarker in precision medicine and is increasingly recognized as relevant to relevance in systemic lupus…

Date: 2025-12-19

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

Abstract: Inotuzumab ozogamicin is increasingly being used as bridging therapy (BT) prior to chimeric antigen receptor T-cell (CAR-T) in relapsed/refractory B-cell acute…

Date: 2025-12-18

Pediatric acute lymphoblastic leukemia relapse and prognosis: key predictors and therapeutic implications

Abstract: Pediatric acute lymphoblastic leukemia (ALL), the most common childhood malignancy, achieves >95% 5-year survival with risk-adapted therapies. Nonetheless, 10%–15% of…

Date: 2025-12-18

Burden of multiple myeloma in Asian countries from 1990 to 2021 and trend prediction for 2050: an analysis based on the Global Burden of Disease Study 2021

Abstract: Multiple myeloma (MM) poses a growing challenge to global public health, with regional disparities in disease burden becoming increasingly prominent. As the most…

Date: 2025-12-18

Case Report: Ectopic Cushing’s syndrome caused by a pancreatic neuroendocrine tumor managed through dual steroidogenesis inhibition and endoscopic ultrasound-guided ethanol ablation

Abstract: Ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (EAS) is a rare complication of neuroendocrine tumors (NETs). Severe hypercortisolism (SH)…

Date: 2025-12-18

Comparative study of 5% permethrin, 10% neem leaf extract, and 10% brotowali stem extract for scabies treatment

Abstract: Scabies, a contagious skin infestation caused by Sarcoptes scabiei var. hominis , remains a significant public health issue, particularly in developing countries.…

Date: 2025-12-18

Knowledge, attitudes, and practices of hand eczema patients in Guangdong, China

Abstract: Hand eczema is a common, debilitating condition affecting quality of life. This study aimed to assess the knowledge, attitudes, and practices (KAP) of patients with hand…

Date: 2025-12-18

Assessing educational needs of sickle cell anemia healthcare providers in sub-Saharan Africa and the Caribbean

Abstract: Sickle cell anemia (SCA) causes childhood morbidity and mortality in resource-limited settings. Identifying educational needs of healthcare providers allows…

Date: 2025-12-18

Unmasking inflammation in juvenile dermatomyositis: myokine profiles of patients and bioengineered human muscle

Abstract: Juvenile dermatomyositis (JDM), a rare autoimmune disease characterized by a type I interferon (IFN) gene signature and muscle weakness, lacks robust biomarkers and…

Date: 2025-12-18

Breastfeeding in Turkey: practices, barriers, and cultural dynamics for global insights

Abstract: Breastfeeding is globally recognized as the cornerstone of infant nutrition, offering unparalleled benefits for maternal and child health. However, exclusive…

Date: 2025-12-18