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Network-informed deconvolution of bulk immune gene co-expression reveals single-cell programs and spatial organization

Abstract: Single-cell RNA sequencing (scRNA-seq) has opened unprecedented possibilities to explore the complexity of the immune system. However, existing methods primarily rely on…

Date: 2026-09-01

Integrating mental and behavioral health providers into VHA pain management teams and oncology clinics: assessment of early implementation from site visits

Abstract: To enhance mental health access and suicide prevention services for Veteran patients in Pain Management Teams and Oncology Clinics, the Veterans Health Administration…

Date: 2026-09-01

Predicting clinically significant medication errors: Development and validation of a risk stratification model using incident reporting data

Abstract: Medication error reporting systems capture large volumes of incidents, yet only a small proportion lead to clinically significant patient outcomes. Distinguishing these…

Date: 2026-09-01

Determinants of self-care practices in patients with breast cancer-related upper limb lymphedema: a cross-sectional analysis

Abstract: To assess the level of self-care practices among patients with BCRL and explore factors associated with these practices. A total of 137 patients with BCRL who received…

Date: 2026-09-01

Augmenting interferon-? and anti-PD-L1 antibody bolsters non-ablative radiotherapy to leverage potent abscopal effect in metastatic cancers

Abstract: The abscopal effect is a systemic anti-tumor immune response induced by local radiotherapy (RT), resulting in regression of distant, non-irradiated tumors. Although…

Date: 2026-09-01

Stakeholder perspectives and requirements for environmental-data-driven capacity forecasting in stroke care: a national survey of German stroke units

Abstract: Stroke remains a major health burden in Europe, with rising absolute case numbers. Atmospheric factors such as air pollution and temperature extremes are increasingly…

Date: 2026-09-01

Prognostic value of combined LDL-C and remnant cholesterol stratification for 24-month major adverse cardiovascular events after primary PCI in patients with STEMI

Abstract: This single-center prospective observational cohort study aimed to investigate the prognostic value of combined low-density lipoprotein cholesterol (LDL-C) and remnant…

Date: 2026-09-01

LVEF-based phenotyping in very old adults hospitalised for heart failure: cardiological discrimination, shared geriatric burden, and treatment gaps

Abstract: We conducted a retrospective observational cohort study in a cardiogeriatric unit to compare cardiological, geriatric, biological, and therapeutic profiles across LVEF…

Date: 2026-09-01

Metabolic phenotype dimensions and longitudinal renal function in type 2 diabetes: a principal component analysis-based approach with UACR integration

Abstract: Type 2 diabetes (T2D) exhibits substantial phenotypic heterogeneity, yet the relationship between multidimensional metabolic phenotypes and longitudinal renal function…

Date: 2026-08-31

Persistent perinatal protein malnutrition and post-weaning high-fat diet induce metabolic syndrome and hepatic UCP2 overexpression in IUGR offspring

Abstract: Adults born with intrauterine growth restriction (IUGR) are at a significantly increased risk of developing metabolic syndrome. Postnatal nutritional patterns are…

Date: 2026-08-31