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Double heterozygous germline pathogenic variants in patients referred to a tertiary cancer genetics clinic in Singapore

Abstract: The increasing use of multigene panel testing has led to a rise in the identification of double heterozygous (DH) pathogenic variants in cancer patients, although their…

Date: 2026-08-25

A two-stage deep-learning framework for image classification of 46 southeast Asian fruit and vegetable categories

Abstract: The ThaiSook mHealth application was designed to promote a healthy lifestyle and mitigate risk factors associated with noncommunicable diseases; one of the…

Date: 2026-08-25

A novel modified-curcumin 2.24 suppresses MMPs in a periodontal-relevant cell culture model: a pilot study

Abstract: Matrix metalloproteinases (MMPs) play critical roles in periodontal tissue destruction. The present study evaluated the efficacy of a novel chemically modified curcumin…

Date: 2026-08-25

The divergent impacts of digital engagement on depression: a longitudinal study of competitive resource mechanisms

Abstract: Digital engagement has become an important factor influencing mental health, yet the complex effects of different usage patterns still require deeper clarification. This…

Date: 2026-08-25

Mental health implications in the older adults of internet access in China

Abstract: Social isolation is a significant factor contributing to mental health issues among the older adults, particularly in societies experiencing rapid population aging.…

Date: 2026-08-25

Comparison of sexual function outcomes after vNOTES and laparoscopic tubal sterilization

Abstract: To compare postoperative sexual function outcomes following vaginal natural orifice transluminal endoscopic surgery (vNOTES) and laparoscopic tubal sterilization (LTS).…

Date: 2026-08-25

Exploratory association of OGTT area under the curve with early-night glycemic patterns and pharmacotherapy use in gestational diabetes mellitus

Abstract: In gestational diabetes mellitus (GDM), the relationship between baseline 75-g oral glucose tolerance test (OGTT) area under the curve (AUC), subsequent continuous…

Date: 2026-08-25

Comparative effectiveness of dienogest versus ethinyl estradiol/levonorgestrel combined oral contraceptive therapy in women with endometriosis-associated chronic pelvic pain

Abstract: To compare the clinical effectiveness of combined oral contraceptive pills (levonorgestrel-containing COC) and dienogest in the management of endometriosis-associated…

Date: 2026-08-25

Teaching points in anesthetic management for transcatheter pulmonary valve replacement: a case series

Abstract: Transcatheter pulmonary valve replacement (TPVR) is an established minimally invasive treatment for right ventricular outflow tract dysfunction after repair of…

Date: 2026-08-25

Shifting the paradigm in bipolar disorder: moving beyond conventional inflammatory markers to novel EBI3-containing heterodimeric cytokines

Abstract: Research shows immune dysregulation in bipolar disorder (BD), but clinical heterogeneity and variable treatment responses persist around inflammatory markers like IL-6,…

Date: 2026-08-25