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Prevalence, associated clinical factors, and genetic characteristics of endocrinopathies in common variable immunodeficiency: a retrospective study of 95 adult patients from a single tertiary care center

Abstract: Common variable immunodeficiency (CVID) is the most common clinically significant primary antibody deficiency in adults, characterized by impaired immunoglobulin…

Date: 2026-08-24

Modified McLaughlin procedure combined with proximal humeral locking plate for proximal humeral fractures with posterior shoulder dislocation and reverse Hill-Sachs lesion: a retrospective case series

Abstract: Proximal humeral fractures with posterior shoulder dislocation are rare, high-energy injuries that pose significant treatment challenges. This study aimed to evaluate…

Date: 2026-08-24

Exercise intervention modulates food reward in obesity: efficacy, mechanisms, and prospects

Abstract: Aberrant food reward processing is a key contributor to the development and maintenance of obesity, and exercise intervention has been proposed as a feasible way to…

Date: 2026-08-24

Clinical trajectories after preoperative traditional Chinese medicine in biologic-refractory surgery- intended acute severe ulcerative colitis: an exploratory retrospective case series

Abstract: Acute severe ulcerative colitis (ASUC) is a life-threatening condition, and biologic-refractory patients may ultimately require surgery. The clinical role of…

Date: 2026-08-24

The microenvironment in canine mast cell tumors: association between tumor-associated tissue eosinophilia and histological grade

Abstract: Canine mast cell tumors (MCTs) are common neoplasms with heterogeneous biological behavior, and histological grading alone may not fully reflect their aggressiveness.…

Date: 2026-08-24

Knowledge–practice concordance and discrepancies in very old adults

Abstract: Health-related knowledge is often considered a prerequisite for health behavior, but knowledge may not always translate into everyday practice. This study examined…

Date: 2026-08-24

Integrating clinical and economic outcomes in the elderly myeloma management: a comparative cost-effectiveness analysis

Abstract: Multiple myeloma (MM) is a hematologic malignancy that predominantly affects older adults and poses substantial therapeutic challenges due to the high prevalence of…

Date: 2026-08-24

Public awareness, attitudes, and concerns regarding pharmacogenomics in the Kingdom of Saudi Arabia: an exploratory online cross-sectional survey

Abstract: Pharmacogenomics (PGx) is a cornerstone of precision medicine, enabling tailored drug therapy based on an individual’s genetic profile. However, public awareness,…

Date: 2026-08-24

Preventing relapse in ulcerative colitis remission maintenance: machine learning prediction and reinforcement-learning herbal prescription optimization with external validation

Abstract: Maintaining remission in ulcerative colitis (UC) with traditional Chinese herbal medicine is challenging because fixed-intensity prescriptions may not accommodate…

Date: 2026-08-24

Navigating the Generosity of Medicines (Gen-MED): characterizing the complex relationships of medication donations in Japan through stakeholder and social network analysis

Abstract: Anthropogenic and natural hazards increase reliance on donated medicines. However, inappropriate donations (e.g., expired, unlabeled, or poorly matched to local needs)…

Date: 2026-08-24