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Multi-omics analysis identifies fibroblast IGFBP5 as a key target of anti-TNF? therapy in ulcerative colitis

Abstract: Resistance to anti-TNF? therapy (e.g., infliximab) in ulcerative colitis (UC) remains a significant clinical challenge, with the underlying cellular and spatial…

Date: 2026-08-20

Washed microbiota transplantation is associated with Helicobacter pylori -negative conversion and circulating group 2 innate lymphoid cell profiles

Abstract: Antibiotic resistance remains a major challenge in the management of Helicobacter pylori ( H. pylori ) infection. Microbiota-based interventions, including washed…

Date: 2026-08-20

Documented inpatient aspirin use and in-hospital mortality in non-HIV tuberculous meningitis: a propensity score-weighted retrospective cohort study

Abstract: Aspirin has antiplatelet and anti-inflammatory effects that may be relevant to cerebrovascular complications of tuberculous meningitis (TBM), but its association with…

Date: 2026-08-20

Pre-treatment T cell features and immune-milieu characteristics shape treatment-induced exhaustion and resistance to Blinatumomab in B-cell acute lymphoblastic leukemia

Abstract: Blinatumomab (Blina), a CD19×CD3 bispecific T cell engager, is approved for the treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), yet resistance…

Date: 2026-08-20

Longitudinal immune profiling demonstrates persistent MAIT cell reduction and temporal cytokine alterations after aneurysmal subarachnoid hemorrhage

Abstract: Neuroinflammation and systemic immune dysregulation are increasingly recognized as key contributors to secondary brain injury after aneurysmal subarachnoid hemorrhage…

Date: 2026-08-20

UBA1 enhances phagocytosis by suppressing CD47 expression in small cell lung cancer

Abstract: Small cell lung cancer (SCLC) exhibits a limited overall response rate to immunotherapy, largely due to its highly immunosuppressive microenvironment. CD47, an innate…

Date: 2026-08-20

Exploring medication adherence and risk factors in elderly patients with hepatocellular carcinoma undergoing oral targeted therapy: a cross-sectional observational study

Abstract: Oral targeted therapy is now integral to the management of older adults with hepatocellular carcinoma (HCC), yet suboptimal adherence persistently undermines its…

Date: 2026-08-20

Single-cell transcriptomics and a boundary wound model reveal temporal decoupling and microenvironmental heterogeneity in radiation-induced fibrosis

Abstract: Radiotherapy is a key treatment method for cancer, but high-dose treatment can lead to damage to normal tissues and chronic fibrosis. There is a lack of systematic…

Date: 2026-08-20

Comparative analysis of two radial hemostasis strategies following percutaneous coronary intervention: a prospective, single-center, real-world cohort study

Abstract: Radial access is currently the approach of choice for coronary interventional procedures. However, puncture and hemostasis are not exempt from access site complications.…

Date: 2026-08-20

The application of drug-coated balloon to in situ short and long lesions of large coronary artery vessels

Abstract: To observe the efficacy of drug-coated balloon (DCB) in the treatment of in situ short (reference diameter ?2.8?mm) and long lesions (reference diameter ?2.8?mm, length…

Date: 2026-08-20