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Clinicopathological features and diagnostic intervals of second primary breast cancer following a prior malignancy: a single-center retrospective study

Abstract: As cancer survival improves, the number of patients at risk of a second primary malignancy (SPM) is increasing. Previous research has focused mainly on SPMs after breast…

Date: 2026-08-17

Development of humanized mouse models for the preclinical evaluation of NK cell-based therapies

Abstract: Novel immunotherapeutic strategies engaging human Natural Killer (huNK) cells have emerged as a promising treatment paradigm; however, their accurate preclinical…

Date: 2026-08-17

Thirty years of NCI thyroid cancer research investment (1996–2025): a longitudinal portfolio analysis of funding trends, molecular target emphasis and thematic evolution

Abstract: Thyroid cancer research has shifted over the past three decades toward molecular classification, precision diagnostics and targeted therapy. However, the evolution of…

Date: 2026-08-17

High dose IFN-?2b as post operative adjuvant therapy for acral melanoma: a multi-center real-world cohort study of 171 Chinese patients

Abstract: This study aimed to investigate recurrence patterns and survival outcomes in Chinese patients with AM who received postoperative adjuvant High-dose interferon (HD-IFN),…

Date: 2026-08-17

Establishment and clinical performance evaluation of the thyroglobulin colloidal gold immunochromatographic assay

Abstract: Lymph node metastasis increases recurrence risk in differentiated thyroid carcinoma (DTC). To address limitations of conventional detection, this study developed a novel…

Date: 2026-08-17

Thrombotic complications in patients treated with immune checkpoint inhibitors: a retrospective study of incidence, risk factors, and survival outcomes

Abstract: Immune checkpoint inhibitors (ICIs) have transformed cancer outcomes across multiple malignancies. However, emerging evidence suggests that thrombotic events, including…

Date: 2026-08-14

Scale-up of the Diactive-1 mHealth program integrating tailored resistance training as an educational strategy for self-management in children and adolescents with type 1 diabetes: protocol for an 11-hospital multicenter randomized controlled trial

Abstract: Physical activity is strongly recommended for youth with type 1 diabetes, yet many children and adolescents do not meet current exercise guidelines, partly because of…

Date: 2026-08-14

Early-pregnancy trunk phase angle derived from bioelectrical impedance analysis for the prediction of gestational diabetes mellitus

Abstract: To evaluate first-trimester predictors of gestational diabetes mellitus (GDM) and develop an early risk model. Women at 8–12 weeks of gestation who attended routine…

Date: 2026-08-14

Type 17 T-cell subset divergence in hidradenitis suppurativa versus psoriasis: a comparative single-cell transcriptomic analysis

Abstract: IL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of…

Date: 2026-08-14

Effects of fractional laser combined with amorolfine hydrochloride cream on fungal clearance rate and nursing outcomes in patients with onychomycosis: a retrospective clinical study

Abstract: To investigate the clinical efficacy, fungal clearance rate, and impact on quality of life of fractional laser combined with amorolfine hydrochloride cream in the…

Date: 2026-08-14