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Interpretable machine learning enables early identification of financial risk and resource optimization in colorectal cancer surgery

Abstract: Colorectal cancer (CRC) imposes major clinical and economic pressure on health systems. Under diagnosis-related group (DRG) payment, fixed reimbursement benchmarks may…

Date: 2026-08-14

Two-hour dynamic reassessment of noninvasive ventilation failure risk in acute exacerbation of chronic obstructive pulmonary disease with hypercapnic respiratory failure: development and temporal validation

Abstract: Early recognition of noninvasive ventilation (NIV) failure remains difficult in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic…

Date: 2026-08-14

Investigation of clinical applicability of deep learning-based virtual contrast-enhanced MRI for nasopharyngeal carcinoma patients

Abstract: There is a lack of research evaluating the clinical performance of virtual contrast-enhanced MRI (VCE-MRI). This study aims to assess the clinical utility of an…

Date: 2026-08-14

Gantry-period-guided modulation factor selection in helical tomotherapy: effects on delivery efficiency, dosimetry and verification accuracy

Abstract: To explore a gantry-period-guided strategy for identifying a lower useful modulation factor (MF) in helical tomotherapy under fixed field width and pitch. Twenty…

Date: 2026-08-14

Metformin modulates the phenotypes of tumor-associated macrophages in glioblastoma in a context-dependent manner by promoting the homeostasis of macrophages

Abstract: Glioblastoma (GBM) remains the most aggressive primary adult brain cancer attributed to its immunosuppressive nature. Radiation therapy (RT) and concurrent temozolomide…

Date: 2026-08-14

Early dynamic immune-inflammatory and nutritional recovery signature is associated with durable benefit and early progression in advanced non-small cell lung cancer receiving first-line PD-1/PD-L1 inhibitor-based therapy: a real-world retrospective cohort study

Abstract: Durable benefit from first-line PD-1/PD-L1 inhibitor-based therapy remains heterogeneous in advanced non-small cell lung cancer (NSCLC). Baseline biomarkers, including…

Date: 2026-08-14

Relation of climatic exposures with intrahepatic cholestasis of pregnancy in a two-center retrospective cohort

Abstract: To investigate relation between climatic exposures and intrahepatic cholestasis of pregnancy (ICP) in Chinese cities Shanghai and Sanya. ICP is a pregnancy-specific…

Date: 2026-08-14

Building an interpretable machine learning prognosis prediction model-based on baseline examinations of patients with esophageal cancer undergoing surgery

Abstract: To create an interpretable machine learning model based on non-invasive biomarkers for the early diagnosis and improved prognostic value of esophageal cancer. We…

Date: 2026-08-14

Targeted therapy plus chemotherapy for advanced or metastatic triple-negative breast cancer: a PRISMA 2020 systematic review and meta-analysis

Abstract: To systematically review the efficacy of chemotherapy combined with targeted therapy in the handling of advanced triple-negative breast cancer (TNBC). A thorough…

Date: 2026-08-14

Metabolic, inflammatory, and lipoprotein(a)-related risk profiling for incident ASCVD: a multi-biomarker study

Abstract: Metabolic dysfunction, inflammation, and lipoprotein(a) [Lp(a)] reflect different biomarker domains associated with atherosclerotic cardiovascular disease (ASCVD) risk.…

Date: 2026-08-14