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Genetic profile of motor neuron disease in a multiregional Brazilian cohort: an 18-year real-world experience in 1,911 patients

Abstract: Genetic testing in amyotrophic lateral sclerosis (ALS) is increasingly recommended for all patients, but real-world implementation in middle-income countries remains…

Date: 2026-08-05

Analysis of the temporal changes in management of early-stage cervical cancer over a 10-year period in Germany: a multicenter retrospective analysis of the JAGO/NOGGO

Abstract: Surgical management of early-stage cervical cancer has evolved substantially over the past decade. While the LACC trial raised concerns regarding minimally invasive…

Date: 2026-08-05

Regional dietary patterns and their impact on maternal, placental, and fetal fatty acid profiles during pregnancy: a multicenter study from Croatia

Abstract: Maternal dietary fat quality during pregnancy plays a crucial role in fetal growth, neurodevelopment, and long-term metabolic health. Regional dietary patterns may…

Date: 2026-08-05

High-dose folic acid therapy ameliorates gut microbiota dysbiosis in reproductive-aged women with hyperhomocysteinemia

Abstract: Hyperhomocysteinemia (HHCY) in reproductive-aged women is associated with adverse pregnancy outcomes. Although folic acid effectively lowers serum homocysteine (HCY),…

Date: 2026-08-05

Mitochondrial DNA copy number as a biomarker of oxidative stress and inflammation in premature ovarian insufficiency

Abstract: To examine how mitochondrial DNA copy number (mtDNAcn) relates to oxidative stress and persistent inflammation in individuals with premature ovarian insufficiency (POI).…

Date: 2026-08-05

Determination of the median effective dose (ED??) of oliceridine combined with propofol for inhibiting gastroscope insertion responses in adult patients undergoing painless gastroscopy

Abstract: Propofol is the most frequently administered intravenous anesthetic in painless gastroscopy. Oliceridine, a novel ? -opioid receptor agonist, exhibits analgesic effects…

Date: 2026-08-05

Clients’ views and experiences of individual placement and support: an employment program for people in treatment for substance use

Abstract: Individual Placement and Support (IPS) was originally developed to help people with serious mental illnesses into competitive employment but has recently shown positive…

Date: 2026-08-05

Experiences of parents and adolescents throughout the solid-organ transplantation process: a focus group study

Abstract: Solid-organ transplantation is the optimal treatment for children and adolescents with end-stage organ failure. However, the biopsychosocial challenges faced jointly by…

Date: 2026-08-05

Characteristics of subclinical seizures in an adult epilepsy population—a retrospective observational study

Abstract: Subclinical seizures (SCSs) are commonly detected during video-EEG monitoring but frequently overlooked in clinical practice. Their prevalence, localization…

Date: 2026-08-05

Feasibility and effectiveness of a manualized group psychotherapy program for autistic adults: a naturalistic clinical study

Abstract: Psychosocial interventions for autistic adults remain limited. This study evaluated the implementation feasibility and potential clinical effectiveness of a manualized…

Date: 2026-08-05