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Frailty combined with nutritional risk for predicting stroke-associated pneumonia: a cohort study based on a nomogram model

Abstract: Stroke-associated pneumonia (SAP) is a common and serious complication in patients with acute severe stroke, and existing risk assessment tools have limited predictive…

Date: 2026-07-31

Carotid intraplaque neovascularization and cerebral microbleeds: correlation assessed by plane-wave ultrasensitive flow imaging

Abstract: Carotid intraplaque neovascularization (IPN) is a marker of plaque vulnerability, whereas cerebral microbleeds (CMBs) are established markers of cerebral small vessel…

Date: 2026-07-31

Development of a predictive tool for hemophagocytic lymphohistiocytosis/macrophage activation syndrome risk in adult-onset Still’s disease

Abstract: Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) is one of the most common complications of adult-onset Still’s disease (AOSD), and a leading…

Date: 2026-07-31

ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC

Abstract: Immune checkpoint inhibitors (ICIs) have improved outcomes in advanced non-small cell lung cancer (NSCLC), but clinical benefit remains heterogeneous and is not fully…

Date: 2026-07-31

Vertebral body dosimetry associated with hematologic toxicities and survival in esophageal squamous-cell carcinoma treated with chemoradiotherapy plus immunotherapy

Abstract: The addition of immunotherapy to definitive chemoradiotherapy has improved outcomes for patients with unresectable advanced esophageal squamous-cell carcinoma (ESCC).…

Date: 2026-07-31

Epidemiological surveillance of childhood and adolescent malignancies as a tool for public health strategy: insights from the Polish National Cancer Registry 2023

Abstract: Pediatric malignancies require specialized epidemiological surveillance due to their distinct developmental etiology and unique societal impact. In the context of…

Date: 2026-07-31

The lactate-to-albumin ratio as a potential biomarker for acute kidney injury risk in critically ill patients with heart failure: a retrospective study with real-world external validation

Abstract: The lactate-to-albumin ratio (LAR) is a composite biomarker that integrates measures of nutritional status, systemic inflammation, and oxidative stress in critically ill…

Date: 2026-07-31

Urinary organophosphate metabolites, DNA methylation aging, and heart disease mortality in middle-aged and older adults: an exploratory cohort study with in vitro evidence of biological plausibility

Abstract: Chronic low-dose exposure to organophosphorus pesticides (OPPs) is widespread in the general population and has been linked to heart disease mortality, yet the…

Date: 2026-07-31

Association of C-reactive protein-albumin-lymphocyte index and coronary artery calcification on major adverse cardiovascular events of dialysis patients with acute coronary syndrome

Abstract: Inflammation, immune dysfunction, malnutrition and severe coronary artery calcification (CAC) are critical cardiovascular risk factors in patients on dialysis. However,…

Date: 2026-07-31

Prognostic value of a novel indicator integrating C-reactive protein-triglyceride glucose index and coronary physiological burden in patients undergoing PCI: a prospective cohort study

Abstract: Patients with coronary artery disease (CAD) continue to face residual cardiovascular risk despite receiving guideline-directed optimal therapy. Both systemic…

Date: 2026-07-31