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Development and validation of an interpretable predictive model for mismatch between endoscopic ultrasonography and histopathological diagnosis in colorectal subepithelial lesions: a retrospective single-center study

Abstract: Endoscopic ultrasonography (EUS) is important for evaluating colorectal subepithelial lesions (SELs), but EUS–histopathology mismatch may complicate preoperative…

Date: 2026-07-30

BRTO-assisted endoscopic cyanoacrylate injection as a potential therapy for intractable acute gastric variceal bleeding with large SPSS: a retrospective single-center case series study

Abstract: Treatment of acute gastric variceal bleeding (AGVB) in patients with large spontaneous portosystemic shunts (SPSS) remains challenging due to the severe, refractory…

Date: 2026-07-30

Uncovering the associative mediation pathway from EUS features to malignancy through pathological mediators in gastrointestinal stromal tumor

Abstract: Endoscopic ultrasound (EUS) plays a pivotal role in preoperative risk stratification of gastrointestinal stromal tumors (GISTs); however, the biological mechanisms…

Date: 2026-07-30

Clinical correlates, procedural benchmarks, and reperfusion–outcome dissociation after mechanical thrombectomy for acute large-vessel occlusion stroke: a single-center retrospective registry study

Abstract: Endovascular thrombectomy (EVT) is an established treatment for selected patients with acute ischemic stroke caused by large-vessel occlusion (LVO). Single-center…

Date: 2026-07-30

Assessing efgartigimod dosing patterns and Myasthenia Gravis Activities of Daily Living outcomes in clinical practice: results from a large patient support program database

Abstract: Efgartigimod, a neonatal Fc receptor (FcRn) blocker, is approved for the treatment of generalized myasthenia gravis (gMG). Evidence describing large-scale cohorts in…

Date: 2026-07-30

Clinical and immunological features of rheumatoid arthritis patients with positive anti-centromere antibody: a case-control study

Abstract: To characterize the clinical and immunological features of rheumatoid arthritis (RA) patients with positive anti-centromere antibody (ACA). In this retrospective…

Date: 2026-07-30

B cell receptor–based hybridoma enrichment enables discovery of antibodies against intracellular tumor antigens

Abstract: Tumor-associated B cell responses are frequently observed in tumors and their draining lymph nodes, yet their antigen specificities and functional potential remain…

Date: 2026-07-30

Efficacy of immune checkpoint inhibitors combined with different chemotherapy in recurrent pancreatic cancer: a retrospective study

Abstract: Recurrence affects 65%-75% of pancreatic cancer (PC) patient post-resection. Established salvage strategies for recurrent PC are lacking, and systemic chemotherapy…

Date: 2026-07-30

Risk factor analysis and prediction of lower-extremity deep vein thrombosis after surgery in patients with non-small cell lung cancer

Abstract: Postoperative lower-extremity deep vein thrombosis (DVT) remains a clinically relevant complication after surgical resection for non-small cell lung cancer (NSCLC). This…

Date: 2026-07-30

Beyond IMDC: do expanded models improve survival discrimination in metastatic renal cell carcinoma? A real-world cohort study

Abstract: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) classification remains the cornerstone of prognostic assessment in metastatic renal cell…

Date: 2026-07-30