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Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation

Abstract: Mitral (MR) and tricuspid regurgitation (TR) are common valvular disorders that may progress over time. Atrial fibrillation (AF) affects atrial structure and may…

Date: 2026-07-01

Reduced platelet count in mice protects against glucose intolerance and beta cell loss during a long-term high-fat diet

Abstract: Platelets promote hemostasis and modulate different inflammatory and immunological processes. Recently, it was reported that platelets interact with pancreatic beta…

Date: 2026-07-01

The role of the NLRP3 inflammasome in hypertension-related chronic heart failure and its potential therapeutic targets

Abstract: Hypertension-induced pressure overload is a major driver of chronic heart failure (CHF) and is accompanied by persistent sterile inflammation. However, the upstream…

Date: 2026-07-01

Gastrointestinal adverse reactions and metabolism–nutrition disorders associated with hypomethylating agents: a pharmacovigilance study with exploratory mechanistic analysis

Abstract: Hypomethylating agents, particularly azacitidine and decitabine, are widely used for the treatment of myelodysplastic syndromes and acute myeloid leukemia.…

Date: 2026-06-30

Prognostic value of the atherogenic index of plasma for early-stage diabetic kidney disease in type 2 diabetes: a retrospective cohort study using supervised machine learning

Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD). Its insidious onset means that once it progresses to the stage of heavy proteinuria…

Date: 2026-06-30

Vitamin K status has no influence on the effect of vitamin D supplementation on bone turnover and cardiovascular markers: a randomized controlled trial

Abstract: Vitamin K and D co-treatment may have additive effects on bone and cardiovascular health and is frequently used as an over-the-counter supplement. The primary aim of…

Date: 2026-06-30

Development and validation of a predictive model for diabetic kidney disease risk in patients with T2DM: a hospital data platform study

Abstract: This study used clinical data from patients with type 2 diabetes mellitus (T2DM) and applied least absolute shrinkage and selection operator (LASSO) regression to…

Date: 2026-06-30

Inflammation and nutrition-derived indicators for predicting amputation risk in patients with type 2 diabetic foot ulcers

Abstract: Inflammation and malnutrition affect the prognosis of diabetic foot ulcers (DFU). This study systematically evaluated the impact and predictive value of inflammation and…

Date: 2026-06-30

Systemic skewing of peripheral blood leukocyte composition in neurofibromatosis type 1

Abstract: The present study aimed to characterize neurofibromatosis type 1 (NF1)-associated alterations in peripheral white blood cell differentials, focusing on overall patterns…

Date: 2026-06-30

Awareness and attitudes of parents towards pediatric dentistry and children's oral health: a cross-sectional study

Abstract: Parents play a pivotal role in shaping children's oral health behaviors and practices. This study aimed to assess parental awareness and attitudes regarding children's…

Date: 2026-06-30