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MicroRNA-383-5p regulation of NADPH oxidase 4 alleviates hemorrhagic transformation and improves acute outcomes after endovascular recanalization in acute ischemic stroke

Abstract: Hemorrhagic transformation (HT) following reperfusion therapy is associated with poor outcomes in patients with acute ischemic stroke. Here, we determined the role of…

Date: 2026-06-24

A nomogram integrating DCE-MRI imaging features and clinicopathological parameters for predicting pathological complete response in HER2-positive breast cancer

Abstract: HER2-positive breast cancer represents approximately 15-20% of all breast cancers and is characterized by aggressive biological behavior. Neoadjuvant chemotherapy (NAC)…

Date: 2026-06-24

Circumferential laryngopharyngectomy with free jejunal transfer for hypopharyngeal cancer: a retrospective cohort analysis of outcomes and complications

Abstract: Hypopharyngeal squamous cell carcinoma (HSCC) is often diagnosed at an advanced stage and characterized by poor prognosis. While primary (chemo)radiotherapy is…

Date: 2026-06-24

Fecal microbiome and metabolome dynamics during immunotherapy-based total neoadjuvant therapy in rectal cancer: associations with treatment response and toxicity

Abstract: Immunotherapy-based total neoadjuvant therapy (iTNT) is a promising strategy for microsatellite-stable locally advanced rectal cancer (LARC), yet therapeutic response…

Date: 2026-06-24

Efficacy of tumor treating fields in high-grade glioma: a real-world retrospective analysis of 28 patients

Abstract: To evaluate the efficacy of Tumor Treating Fields (TTFields) in 28 patients with high-grade gliomas in a real-world setting. A retrospective analysis was performed on 19…

Date: 2026-06-24

Pan-immune-inflammation value predicts 2-year recurrence after chemoradiotherapy in nasopharyngeal carcinoma

Abstract: Nasopharyngeal carcinoma (NPC) remains a clinically challenging head and neck malignancy with a substantial risk of post-treatment recurrence, underscoring the need for…

Date: 2026-06-24

Trends, survival and regional control of sentinel lymph node biopsy versus axillary dissection in cN0 breast cancer: a multicenter cohort in China

Abstract: Trials show that sentinel lymph node biopsy (SLNB) can replace completion axillary lymph node dissection (ALND) for selected cN0 patients without compromising survival…

Date: 2026-06-24

Outcomes of malignant orbital tumors: a 22-year Norwegian single-center series

Abstract: To evaluate outcome data for patients with malignant orbital tumors treated at Haukeland University Hospital over a 22 year period and compare them with existing…

Date: 2026-06-24

TRPV1-mediated calcium signaling underlies the synergistic pro-apoptotic effects of lidocaine and melatonin in SH-SY5Y neuroblastoma cells

Abstract: Lidocaine, an amide-type local anesthetic, and melatonin, a multifunctional indoleamine with mitochondrial regulatory and anticancer properties, have each been reported…

Date: 2026-06-24

NRS2002-stratified body composition and laboratory characteristics in hospitalized cancer patients assessed by bioelectrical impedance analysis

Abstract: The body composition and laboratory characteristics underlying Nutritional Risk Screening 2002 (NRS2002)-defined nutritional risk in hospitalized patients with cancer…

Date: 2026-06-24