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Identification and experimental validation of CD74, PGLYRP1, and TXN as potential biomarkers in rheumatoid arthritis: an integrative bulk and ScRNA-seq study

Abstract: Chronic joint inflammation, the hallmark of rheumatoid arthritis (RA), is an autoimmune condition that commonly leads to progressive joint damage and dysfunction. While…

Date: 2026-06-23

Comparative study on the efficacy of conservative treatment and surgical treatment for simple Mason II radial head fracture

Abstract: This study aimed to analyze the therapeutic effects of conservative fixation with braces vs. open reduction with internal fixation surgery for simple Mason II radial…

Date: 2026-06-23

Clinical outcomes after single-level posterior lumbar interbody fusion in osteoporotic patients with or without paraspinal muscle atrophy: a retrospective study

Abstract: Lumbar disc herniation (LDH) is a major cause of low back pain and disability. In osteoporotic patients undergoing posterior lumbar interbody fusion (PLIF),…

Date: 2026-06-23

Divergent risk profiles for cause-specific mortality in MASLD and MetALD: a nationwide population-based study

Abstract: Metabolic-dysfunction-associated steatotic liver disease (MASLD) and MASLD with increased alcohol intake (MetALD) are overlapping but distinct conditions that influence…

Date: 2026-06-23

Integrated multi-omics analysis reveals distinct microbiota-metabolite signatures and a novel HCN2-2-hydroxybutyric acid interaction in inflammatory bowel disease

Abstract: Gut microbiota-derived short-chain fatty acids (SCFAs) exert critical regulatory functions in inflammatory bowel disease (IBD). However, integrated profiling of fecal…

Date: 2026-06-23

Endovascular thrombectomy in selected patients with active cancer and thrombocytopenia: outcomes under an institutional platelet transfusion practice

Abstract: Thrombocytopenia is common in patients with active cancer and large vessel occlusion (LVO), raising safety concerns regarding endovascular thrombectomy (EVT). Therefore,…

Date: 2026-06-23

Combined biofeedback and vestibular rehabilitation therapy for vestibular migraine: clinical efficacy and neurobiochemical correlates

Abstract: Vestibular migraine (VM) is a prevalent cause of recurrent vertigo with limited standardized treatment options. While vestibular rehabilitation and biofeedback therapy…

Date: 2026-06-23

The application effect of mini midline catheters in intravenous therapy for neurology patients: real-world evidence from eastern China

Abstract: To investigate the application effect of ultrasound-guided combined with Accelerated Seldinger Technique (AST) for mini midline catheter placement in patients in the…

Date: 2026-06-23

Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

Abstract: Lung cancer is characterized by high metastatic potential and poor clinical outcomes, underscoring the need for novel approaches to investigate mechanisms regulating…

Date: 2026-06-23

Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial

Abstract: Patients with active ankylosing spondylitis (AS) exhibit substantial heterogeneity in their clinical responses to tumor necrosis factor alpha inhibitors (TNFi).…

Date: 2026-06-23