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Dynamic evolution of readmission risk factors across short-, medium-, and long-term horizons in type 2 diabetes: a machine learning-based predictive modeling study with SHAP interpretability

Abstract: T2DM readmission risk factors may evolve across time windows, but this dynamic remains poorly understood. This retrospective cohort study developed nine machine learning…

Date: 2026-06-22

The linear association between vitamin B12 and diabetic retinopathy in type 2 diabetic patients: a cross-sectional study

Abstract: To examine the association between serum vitamin B12 levels and the prevalence of diabetic retinopathy (DR) among adults with type 2 diabetes mellitus (T2DM). This study…

Date: 2026-06-22

Glycogen metabolic dysfunction in T2DM with MASLD: linking ?-hydroxybutyrate to GYS2 downregulation

Abstract: This study aimed to investigate the molecular characteristics of T2DM with MASLD in a C57 mouse model, using multi-omics techniques to identify key nutritional…

Date: 2026-06-22

Glycemic variability and muscle loss in elderly type 2 diabetes: insights from continuous glucose monitoring and chest CT in 303 patients

Abstract: Sarcopenia is common among older adults with type 2 diabetes mellitus (T2DM). Although chronic hyperglycemia is known to contribute to muscle loss, it remains unclear…

Date: 2026-06-22

Oncolytic virotherapy counteracts the selection of IFN-unresponsive cancer cells post-immunotherapy but is limited by the emergence of dedifferentiated cancer cells

Abstract: Genetic mutations disrupting interferon (IFN) signaling have been described as an evolutionary route for tumor cells to evade immune checkpoint inhibitor (ICI) therapy.…

Date: 2026-06-22

Clinical characteristics, predictive factors, and therapeutic outcomes of mycoplasma pneumoniae pneumonia with pleural effusion in children: a retrospective cohort study

Abstract: To analyze the clinical characteristics, predictive factors and curative effects of mycoplasma pneumoniae (MP) infection combined with pleural effusion in children. The…

Date: 2026-06-22

Mindsets impact training adaptation and high-pressure performance: beliefs and perceptions of professionals working in elite sport and mission critical teams

Abstract: A critical objective in professional sports and mission critical teams such as specialist police units, military special forces and emergency medicine responders is…

Date: 2026-06-22

Association of metabolic dysfunction-associated steatotic liver disease trajectories with incident liver cancer: a UK Biobank cohort study

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a contributor to hepatocellular carcinoma. Whether repeated assessment of…

Date: 2026-06-22

Associations with the quality of life of adult family members or partners (informal carers) of people with leukaemia: results from a cross-sectional online global survey

Abstract: Receiving a leukaemia diagnosis and undergoing treatment impact patients and their informal carers. Our objective was to explore and quantify the impact on the quality…

Date: 2026-06-22

Trajectories of perceived household chaos and youth health outcomes across the COVID-19: insights from individual, dyadic, and triadic family analyses

Abstract: The COVID-19 pandemic profoundly disrupted youth development; however, limited studies have explored the diverse patterns of household environments and their…

Date: 2026-06-22