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The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8 + T cell homeostasis and activation

Abstract: Cytoskeletal remodelling is central to naive T cell fitness, organizing receptor-proximal signaling and mechanotransduction during TCR engagement. However, how…

Date: 2026-06-15

Ischemia-modified albumin in children with clinically suspected acute myocarditis: diagnostic performance and incremental value beyond conventional biomarkers

Abstract: Pediatric acute myocarditis is challenging because presentations range from chest pain to cardiogenic shock, and no single biomarker reflects its inflammatory, ischemic,…

Date: 2026-06-15

Real-world effectiveness and safety of dupilumab therapy in children ?6 years with uncontrolled persistent asthma: a propensity-matched retrospective cohort study

Abstract: Asthma is common in children. Dupilumab is a biological agent that showed effectiveness in older children with uncontrolled asthma; however, its efficacy and safety are…

Date: 2026-06-15

Two-year neurodevelopmental outcome in preterm neonates with cerebral oxygenation monitoring after birth: a multinational, multicenter retrospective follow-up study of the COSGOD III trial

Abstract: During immediate neonatal transition, cerebral tissue oxygen saturation (crSO 2 ) exhibits different behavior compared to peripheral arterial oxygen saturation (SpO 2 ).…

Date: 2026-06-15

The herbal pair of Smilax glabra Roxb. and Ficus hirta Vahl. improves exercise performance by regulating mitochondrial function via the adiponection receptors-mediated AMPK signaling pathway

Abstract: Exercise fatigue can significantly impair physical function, while herbal medicines exhibit broad application prospects in anti-fatigue research. The herbal pair of…

Date: 2026-06-15

Hidden distress: a qualitative study of sociocultural barriers to mental health help-seeking among young people in Zimbabwe

Abstract: Sociocultural barriers are powerful forces that may shape how young people experience, interpret, and respond to psychological distress in Zimbabwe. For many youth (aged…

Date: 2026-06-15

A multidimensional ensemble pipeline for early detection of IUGR condition through CTG

Abstract: Introduction: Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality, often associated with placental insufficiency and progressive…

Date: 2026-06-15

Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology

Abstract: The aim of this study was to develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART). This…

Date: 2026-06-15

Inhibition of ferroptosis improves developmental competence of vitrified–warmed oocytes

Abstract: Oocyte vitrification is widely used for female fertility preservation. However, current vitrification procedures can compromise oocyte quality, leading to increased…

Date: 2026-06-15

Surgical treatment and prognosis in patients with intestinal metastases originated from advanced epithelial ovarian cancer

Abstract: To analyze the surgical treatment and prognosis of patients with advanced epithelial ovarian cancer with intestinal metastases. A retrospective study was conducted on…

Date: 2026-06-15