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Clinical features, comorbidities, and therapeutic outcomes of Cushing syndrome: a retrospective multicenter study from Saudi Arabia

Abstract: Cushing syndrome (CS) is associated with significant morbidity and mortality, but data from the Middle East, including Saudi Arabia, are limited. This study aimed to…

Date: 2026-09-23

Clinical profile, reported triggers, and comorbidity pattern in children and adolescents with atopic dermatitis: a cross-sectional study from Fujian, China

Abstract: Detailed clinical descriptions of paediatric atopic dermatitis from southern China are scarce; available Chinese data are largely modelled burden estimates or laboratory…

Date: 2026-09-23

Development and validation of an interpretable machine learning model for predicting ADHD comorbidity in children with allergic rhinitis: a SHAP-based analysis

Abstract: The co-occurrence of allergic rhinitis (AR) and attention-deficit/hyperactivity disorder (ADHD) presents significant clinical challenges in pediatrics, yet predictive…

Date: 2026-09-23

Cuproptosis-related molecular alterations in a neonatal rat model of hypoxic–ischemic brain damage

Abstract: Copper homeostasis imbalance is closely linked to the progression of various neurological disorders. Cuproptosis, a recently identified form of cell death caused by…

Date: 2026-09-23

Short-term changes in clinical parameters associated with telitacicept in pediatric IgA nephropathy: a single-center self-controlled observational study

Abstract: Progressive IgA nephropathy (IgAN) in childhood presents challenges for treatment. Telitacicept has shown significant benefits in adult IgAN patients, warranting…

Date: 2026-09-23

Supportive care and in-hospital mortality among children with suspected sepsis in Bamako, Mali

Abstract: Sepsis causes significant pediatric hospitalizations and deaths globally. The impact of supportive care interventions remains under-studied in sub-Saharan Africa, where…

Date: 2026-09-23

Comparative clinical efficacy and immunological modulation of subcutaneous vs. sublingual allergen immunotherapy in children with house dust mite-induced allergic asthma: a retrospective cohort study

Abstract: The current study compared the clinical efficacy and immunological effects of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in children with…

Date: 2026-09-23

Necrotizing enterocolitis in very preterm infants: an epidemiological study in Jiangsu, China

Abstract: Epidemiological data focusing on clinical practices for necrotizing enterocolitis (NEC) in China remains scarce. To characterize the incidence, clinical management, and…

Date: 2026-09-23

An interpretable machine-learning model identifies obesity-related metabolic complications in children attending a tertiary obesity clinic

Abstract: Childhood obesity-related metabolic complications are common in Northwest China, yet region-specific evidence and risk-stratification tools are lacking. In a…

Date: 2026-09-23

Regularization via gradient attribution for multiple sclerosis lesion segmentation

Abstract: Accurate segmentation of Multiple Sclerosis (MS) lesions from Magnetic Resonance Imaging (MRI) is fundamental for robust disease monitoring and for the evaluation of…

Date: 2026-09-23