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Early circulating tumor DNA dynamics predict fruquintinib efficacy in refractory metastatic colorectal cancer before imaging

Abstract: Treatment options for refractory metastatic colorectal cancer remain limited, and no biomarkers predict fruquintinib benefit before imaging. This study evaluated whether…

Date: 2026-06-12

Clinical outcomes and quality of life associated with eculizumab in patients with late-onset myasthenia gravis

Abstract: Late-onset myasthenia gravis (LOMG) features prominent immunosenescence, high myasthenic crisis risk, and refractoriness due to comorbidities limiting conventional…

Date: 2026-06-12

The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study

Abstract: This study examined the complex relationships among insomnia, anxiety, frailty, and cognitive function in middle-aged and older adults, testing whether frailty moderates…

Date: 2026-06-12

Metagenomic characterization of gut microbiota in rheumatoid arthritis-associated interstitial lung disease: taxonomic shifts and clinical correlations

Abstract: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation with limited diagnostic biomarkers. While gut microbiota…

Date: 2026-06-12

Heterogeneous immune cell composition in patients with combined immunodeficiency

Abstract: Combined immunodeficiencies (CIDs) are a severe class of inborn errors of immunity characterized by defective T cell development and function, often accompanied by…

Date: 2026-06-12

A federated digital twin reveals cytomegalovirus reactivation impairs CAR-T cell therapy via IL-15-mediated cytokine competition in B-Cell lymphoma

Abstract: Cytomegalovirus (CMV) reactivation occurs in 30 ? 40 % of seropositive patients receiving chimeric antigen receptor T-cell (CAR-T) therapy for B-cell lymphoma and is…

Date: 2026-06-12

Inflammatory biomarker-based prognostic model for immunotherapy outcomes in patients with recurrent or metastatic cervical cancer

Abstract: Conventional predictive biomarkers, including programmed death ligand-1 (PD-L1) expression and tumor mutational burden testing, fail to predict immunotherapy efficacy in…

Date: 2026-06-12

Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single-center experience

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. In children, secondary HLH may occur with infection, rheumatologic disease,…

Date: 2026-06-12

Peripheral immune cell subsets as potential predictors of benefit from immune checkpoint blockade therapy in small cell lung cancer

Abstract: Small cell lung cancer (SCLC) is a lethal neoplasia. Chemotherapy (Ct) plus immune checkpoint blockade therapy (ICBt) is now the standard of care although limited…

Date: 2026-06-12

Group painting therapy for children and adolescents with bone tumors: a quasi-experimental trial evaluating anxiety, depression, post-traumatic growth, and health-related quality of life

Abstract: Children and adolescents undergoing treatment for malignant bone tumors frequently experience heightened psychological distress, including anxiety, depression, and…

Date: 2026-06-12