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Machine learning-based prediction of gout flares during hospitalization in patients with upper gastrointestinal bleeding: a retrospective cohort study

Abstract: Acute gout flares pose a significant therapeutic challenge in hospitalized patients with upper gastrointestinal bleeding (UGIB) due to the contraindications of standard…

Date: 2026-06-10

Clinical and genetic characteristics of children with sodium taurocholate cotransporting poly-peptide deficiency

Abstract: Sodium taurocholate cotransporting polypeptide deficiency (NTCPD) is an autosomal recessive disorder caused by SLC10A1 gene mutations. This study analyzed the clinical…

Date: 2026-06-10

ANGPT1–GABARAP axis modulates NLRP3 inflammasome–mediated pyroptosis in Crohn’s disease

Abstract: Crohn ’ s disease (CD) is characterized by persistent intestinal inflammation, immune dysregulation, and intestinal barrier dysfunction. Inflammasome-mediated pyroptosis…

Date: 2026-06-10

Development and validation of a machine learning model for predicting stroke-associated pneumonia in older patients with acute ischemic stroke

Abstract: Stroke-associated pneumonia (SAP) is a common and serious complication in older patients with acute ischemic stroke (AIS). However, early identification of high-risk…

Date: 2026-06-10

Soluble multi?epitope protein vaccination leverages antigen availability to drive CD8 + T cell immunity and tumor control

Abstract: The shift toward precision medicine in cancer immunotherapy has increased demand for rapid, scalable production platforms for personalized vaccine antigens targeting…

Date: 2026-06-10

Association between the C-reactive protein–triglyceride–glucose index and incident cardiovascular disease in middle-aged and older adults with arthritis: a nationwide prospective cohort study with hospital-based cross-sectional replication

Abstract: Arthritis encompasses heterogeneous joint and rheumatic conditions and is associated with increased cardiovascular disease (CVD) risk. The C-reactive…

Date: 2026-06-10

Influencing factors and path analysis of posttraumatic growth in patients with autoimmune diseases

Abstract: Guided by the Transactional Model of Stress and Coping, this study aimed to construct a structural equation model of posttraumatic growth in patients with autoimmune…

Date: 2026-06-10

Molecular and spatial specialization of lung interstitial macrophage subsets: beyond chemokines

Abstract: Interstitial macrophages (IMs) are increasingly recognized for their vital roles in maintaining tissue homeostasis and orchestrating immune responses. Building on…

Date: 2026-06-10

Trends in the China pathologist workforce From 2010 to 2022

Abstract: Pathology faces a global personnel shortage and increasing workload due to rising cancer cases and diagnostic complexity, yet data in China are lacking. This study…

Date: 2026-06-10

Exploring healthcare professionals’ views on integrative Chinese–Western medicine in the nutritional management of cancer patients: a qualitative study

Abstract: Malnutrition is highly prevalent among cancer patients and significantly impairs recovery and treatment outcomes. In China, Integrative Chinese–Western Nutritional…

Date: 2026-06-10