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Diagnostic performance of 18 F-FDG PET-CT and SPECT for bone metastases from colorectal cancer: a retrospective study

Abstract: To compare the diagnostic performance of 18F-FDG PET-CT and SPECT whole-body bone imaging for detecting bone metastases in patients with colorectal cancer. A…

Date: 2026-06-12

Interpretable machine learning model for predicting postoperative hypoproteinemia in middle-aged and elderly patients following total joint arthroplasty: a multicenter retrospective study

Abstract: Postoperative hypoproteinemia is a prevalent yet frequently overlooked complication following total hip or knee arthroplasty (TJA), adversely impacting wound healing and…

Date: 2026-06-12

A multicenter clinical study on transanal endoscopic sphincter-preserving resection of low rectal tumors

Abstract: Transanal Endoscopic Sphincter-Preserving Resection (TA-ESPR) is a super-minimally invasive endoscopic technique for digestive tract tumors. This study aimed to evaluate…

Date: 2026-06-12

Early circulating tumor DNA dynamics predict fruquintinib efficacy in refractory metastatic colorectal cancer before imaging

Abstract: Treatment options for refractory metastatic colorectal cancer remain limited, and no biomarkers predict fruquintinib benefit before imaging. This study evaluated whether…

Date: 2026-06-12

Clinical outcomes and quality of life associated with eculizumab in patients with late-onset myasthenia gravis

Abstract: Late-onset myasthenia gravis (LOMG) features prominent immunosenescence, high myasthenic crisis risk, and refractoriness due to comorbidities limiting conventional…

Date: 2026-06-12

The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study

Abstract: This study examined the complex relationships among insomnia, anxiety, frailty, and cognitive function in middle-aged and older adults, testing whether frailty moderates…

Date: 2026-06-12

Metagenomic characterization of gut microbiota in rheumatoid arthritis-associated interstitial lung disease: taxonomic shifts and clinical correlations

Abstract: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe extra-articular manifestation with limited diagnostic biomarkers. While gut microbiota…

Date: 2026-06-12

Heterogeneous immune cell composition in patients with combined immunodeficiency

Abstract: Combined immunodeficiencies (CIDs) are a severe class of inborn errors of immunity characterized by defective T cell development and function, often accompanied by…

Date: 2026-06-12

A federated digital twin reveals cytomegalovirus reactivation impairs CAR-T cell therapy via IL-15-mediated cytokine competition in B-Cell lymphoma

Abstract: Cytomegalovirus (CMV) reactivation occurs in 30 ? 40 % of seropositive patients receiving chimeric antigen receptor T-cell (CAR-T) therapy for B-cell lymphoma and is…

Date: 2026-06-12

Inflammatory biomarker-based prognostic model for immunotherapy outcomes in patients with recurrent or metastatic cervical cancer

Abstract: Conventional predictive biomarkers, including programmed death ligand-1 (PD-L1) expression and tumor mutational burden testing, fail to predict immunotherapy efficacy in…

Date: 2026-06-12