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RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression

Abstract: Breast cancer is the most common malignant tumor worldwide, and its high heterogeneity limits the efficacy of current clinical therapies. R-spondin 2 (RSPO2) expression…

Date: 2026-06-09

Subcutaneous patient-controlled analgesia with hydromorphone for the treatment of refractory cancer pain in older hospitalized patients: a retrospective real-world study

Abstract: Refractory cancer pain remains difficult to control in older adults, particularly when oral opioid regimens are limited by dysphagia, nausea, bowel dysfunction, or…

Date: 2026-06-09

SIMVASTATIN as a potential protective strategy against doxorubicin-induced cardiotoxicity

Abstract: Doxorubicin-induced cardiotoxicity (DIC) represents a major limitation in oncology, leading to ventricular dysfunction and long-term morbidity. Lipophilic statins, such…

Date: 2026-06-09

Baseline vs. on-treatment heart failure with preserved ejection fraction (HFpEF) in a real world cardio-oncology clinic: observational analysis of cancer therapy-related cardiovascular toxicity incidence and cancer treatment implications

Abstract: Heart failure with preserved ejection fraction (HFpEF) prevalence increases, but in cancer patients undergoing potentially cardiotoxic treatments, HFpEF is not included…

Date: 2026-06-09

Efficacy and safety of transcatheter left atrial appendage closure guided by transoesophageal echocardiography using standard and micro TEE probes: a single-center retrospective study

Abstract: Transcatheter left atrial appendage closure (T-LAAC) represents an effective alternative to long-term anticoagulation in patients with atrial fibrillation (AF) and…

Date: 2026-06-09

Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study

Abstract: Previous studies have consistently confirmed an association between homocysteine (Hcy) and hypertension. However, whether homocysteine is also associated with diabetes…

Date: 2026-06-09

High prevalence of thyroid nodules and their association with cardiometabolic risk in Mongolia

Abstract: Mongolia faces rising rates of obesity, diabetes, and cardiovascular disease, yet little is known about their relationship with thyroid nodules. This study aimed to…

Date: 2026-06-08

Association between tumor genomic mutations and the risk of PD-1 inhibitor-induced hypophysitis: a retrospective cohort study

Abstract: Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with hypophysitis being a serious endocrine toxicity that often requires hormone…

Date: 2026-06-08

Interaction between fatty pancreas disease and genetically predicted glucose-dependent insulinotropic polypeptide on incident type 2 diabetes: evidence from the UK Biobank

Abstract: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in lipid metabolism. The effect of GIP on pancreatic lipid and whether it modulates risk of type…

Date: 2026-06-08

LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer

Abstract: LncRNAs emerge as critical regulators of gene expression and epigenetic modulation in human cancer. However, the biological and clinical significance of the lncRNA…

Date: 2026-06-08