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Immunotherapy-based adjuvant treatment after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma according to pathological response

Abstract: Neoadjuvant immunochemotherapy (NICT) is increasingly used in patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC). However, optimal…

Date: 2026-06-03

Continuing immune checkpoint inhibitors beyond progression versus switching to non-ICI therapy in advanced gastric cancer: a real-world study

Abstract: The optimal second-line therapy for advanced gastric/gastroesophageal junction cancer (GC/GEJC) following progression on first-line immuno-chemotherapy remains…

Date: 2026-06-03

Docetaxel enhances V?-directed T-cell activation and antitumor immunity mediated by a bifunctional TCR agonist in breast and prostate cancer models

Abstract: STAR0602 is a selective bifunctional T cell agonist targeting V?6/V?10 T-cell receptors fused to interleukin-2, with emerging clinical activity in anti-PDL1–resistant…

Date: 2026-06-03

Elevated PTK6 expression is associated with tumor immune microenvironment remodeling and predicts poor prognosis in endometrial carcinoma

Abstract: Uterine corpus endometrial carcinoma (UCEC) incidence rises globally, with >50% of advanced/recurrent patients showing poor response to immune checkpoint inhibitors due…

Date: 2026-06-03

Acceptability and functional benefits of a health promotion program in pediatric oncology: a mixed-methods study

Abstract: The increasing number of childhood cancer survivors and their well-established risk of cancer-related morbidity strongly support the need for effective health promotion…

Date: 2026-06-03

Senescence-circadian interplay stratifies patient prognosis and reveals immune remodeling heterogeneity in colorectal cancer

Abstract: Colorectal cancer (CRC) exhibits substantial biological and prognostic heterogeneity that is not fully captured by conventional clinicopathological staging, and the…

Date: 2026-06-03

Risk stratification for adjuvant radiotherapy in pathologic T3N0 rectal cancer using a DeepSurv-based survival model

Abstract: The role of adjuvant radiotherapy in patients with pathologic T3N0 rectal cancer remains controversial. Although overall prognosis is favorable, marked heterogeneity…

Date: 2026-06-03

Baicalin and valproic acid synergistically induce hepatocellular carcinoma cell apoptosis via ROS-mediated PTEN upregulation

Abstract: The prognosis of liver cancer remains exceedingly poor. The therapeutic potential of baicalin (BAI), a natural bioactive compound, in treating liver cancer is…

Date: 2026-06-03

Clinical exploration of first-line therapy in metastatic lung adenocarcinoma patients with negative or low PD-L1 expression: a retrospective cohort study

Abstract: Either Programmed cell death protein 1 (PD-1)/Programmed cell death-Ligand protein 1 (PD-L1) inhibitors plus chemotherapy or anti-angiogenic agents plus chemotherapy has…

Date: 2026-06-03

Molecular tumor board availability and organization in sarcoma referral centers in Italy: are we on the right track?

Abstract: With the rapid progress of molecular medicine, new target therapies for solid tumors have become available, leading to the creation of molecular tumor boards (MTBs)…

Date: 2026-06-03