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Dendrobine inhibits anaplastic thyroid cancer progression by targeting the JAK-STAT3 pathway

Abstract: This study aimed to investigate the antitumor effects of dendrobine on ATC cells and its mechanism targeting the JAK-STAT3 pathway. Human ATC cell lines (CAL-62 and…

Date: 2026-06-02

Association of preterm birth with severity of molecularly-confirmed acute viral respiratory illness presenting to the emergency department: a multi-year analysis

Abstract: Prematurity is a recognized risk factor for respiratory morbidity, but its association with illness severity across viral etiologies in contemporary emergency department…

Date: 2026-06-02

Machine learning based development of an early diagnosis signature for distinguishing hospitalized pediatric human respiratory syncytial virus infection from mycoplasma pneumonia

Abstract: The differentiation between human respiratory syncytial virus (HRSV) and mycoplasma pneumoniae (MP) infections in pediatric community-acquired pneumonia (CAP) remains a…

Date: 2026-06-02

Knowledge graph visualization and retrospective analysis of genetic research on pediatric cardiomyopathy (2000–2024)

Abstract: Pediatric cardiomyopathy is a leading cause of heart failure and sudden cardiac death in children, posing a severe threat to their health and lives while imposing a…

Date: 2026-06-02

Genomic diagnosis and multisystem phenotyping in pediatric congenital analbuminemia: clinical, coagulation, and immune signatures

Abstract: Congenital analbuminemia (CAA) is an ultrarare autosomal recessive disorder caused by biallelic pathogenic variants in the ALB gene, leading to absent or severely…

Date: 2026-06-02

New applications of cardiopulmonary exercise testing parameters characterize age-related changes in exercise performance during adolescence

Abstract: Age-related changes in exercise performance during adolescence are complex because of progressive physical and functional changes, in which multiple factors are…

Date: 2026-06-02

Case series analysis of immunophenotypic evolution during recurrence of low-grade endometrial stromal sarcoma: implications for molecular stability and clinical management

Abstract: To investigate the pathological morphology, immunophenotype, and molecular genetic characteristics of recurrent low-grade endometrial stromal sarcoma (LG-ESS) through…

Date: 2026-06-02

Opposing effects of PM2.5 on TSH levels: effect modification by thyroid peroxidase antibody status in a preconception cohort

Abstract: Fine particulate matter (PM2.5) is a significant source of endocrine disrupting chemicals. However, epidemiological evidence linking PM2.5 exposure to thyroid function,…

Date: 2026-06-02

Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study

Abstract: Hyperthyroidism adversely impacts female reproduction, yet its association with in vitro fertilization (IVF) outcomes remains controversial. It remains unknown whether…

Date: 2026-06-02

Cholesterol, high-density lipoprotein, and glucose (CHG) index and incident impaired fasting glucose in Chinese adults: a retrospective longitudinal cohort study

Abstract: Diabetes mellitus poses a critical global public health burden, with impaired fasting glucose (IFG) being a crucial prediabetic state requiring early identification. The…

Date: 2026-06-02