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IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis

Abstract: Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4 + T cells that critically regulates the differentiation and functions of various adaptive and innate…

Date: 2026-06-01

Novel models for predicting individualized outcomes in patients with advanced hepatocellular carcinoma receiving immunotherapy

Abstract: We aim to develop a nomogram that can effectively differentiate target hepatocellular carcinoma (HCC) patients to receive immunotherapy and categorize their risk levels.…

Date: 2026-06-01

Four-dimensional computed tomography ventilation imaging-guided radiotherapy planning in different techniques for lung cancer

Abstract: This simulation study aims to integrate four-dimensional computed tomography (4DCT) ventilation imaging into functional planning using different radiotherapy (RT)…

Date: 2026-06-01

Target receptor expression dictates the selective intra-tumoral targeting of CD8 + T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients

Abstract: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have shown considerable promise as a therapeutic modality in oncology. Despite their ability to target…

Date: 2026-06-01

Establishment and validation of a machine learning-based predictive model for in-hospital mortality risk in acute myocardial infarction patients complicated with diabetes mellitus

Abstract: To develop and validate a machine learning-based (ML) predictive model for in-hospital mortality risk in patients with acute myocardial infarction (AMI) complicated by…

Date: 2026-06-01

Identification and validation of STEAP3 as a ferroptosis-related biomarker in heart failure

Abstract: Heart failure (HF) is a major health threat, with aging and programmed cell death (PCD) playing key roles. However, the link between aging-related PCD (aging-PCD) genes…

Date: 2026-06-01

Outcomes of critically ill pediatric patients after haploidentical stem cell transplantation

Abstract: Haploidentical peripheral blood hematopoietic stem cell transplantation (haploPBSCT) is increasingly performed for both malignant and nonmalignant diseases. This study…

Date: 2026-05-29

A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function

Abstract: There is a complex physiological interaction between the HPT axis and the HPG axis. However, previous studies have primarily focused on individuals with thyroid…

Date: 2026-05-29

Obstructive sleep apnea risk and its association with diabetic foot ulcer in patients with type 2 diabetes

Abstract: Obstructive sleep apnea (OSA) is common in type 2 diabetes (T2D) and may contribute to its chronic complications. Whether STOP-Bang-defined OSA risk is associated with…

Date: 2026-05-29

Predictors of early response to GnRH and gonadotropin therapy in pediatric patients with suspected dual congenital hypogonadotropic hypogonadism: a retrospective single-center study

Abstract: Some patients with congenital hypogonadotropic hypogonadism (CHH) and suspected partial testicular impairment may show variable clinical responses to GnRH and…

Date: 2026-05-29