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A multivariable probability score integrating routine immunoassay results for the immunological assessment of antisynthetase syndrome

Abstract: Accurate detection of anti-aminoacyl–tRNA synthetase autoantibodies (ASA) is central to the diagnosis of antisynthetase syndrome (ASyS). Although immunoprecipitation…

Date: 2026-05-29

Identification of IL7R as a key genetic risk locus in childhood steroid-sensitive nephrotic syndrome and IgA nephropathy

Abstract: Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is a common childhood glomerular disorder characterized by corticosteroid responsiveness, yet frequent relapses…

Date: 2026-05-29

CD32b defines distinct dendritic cell lineages generated from the culture of bone marrow with GM-CSF

Abstract: Culturing bone marrow (BM) with granulocyte macrophage-colony stimulating factor (GM-CSF) is the most commonly used standard method of generating mouse dendritic cells…

Date: 2026-05-29

Clinical phenotype and prognostic determinants of spontaneous pneumomediastinum in anti-MDA5 antibody-positive dermatomyositis

Abstract: To identify the clinical phenotype and prognostic determinants in patients with anti-MDA5 antibody-positive dermatomyositis (MDA5+DM) with spontaneous pneumomediastinum…

Date: 2026-05-29

An advanced, highly sensitive and versatile Cypridina luciferase-based HPV pseudovirus system for broad-spectrum neutralization and non-invasive In vivo monitoring

Abstract: Evaluating next-generation prophylactic human papillomavirus (HPV) vaccines requires high-throughput and scalable neutralization assays spanning a wide array of…

Date: 2026-05-29

Kappa free light chain index in multiple sclerosis and other inflammatory CNS diseases: a pilot single-center study from Argentina

Abstract: Intrathecal immunoglobulin synthesis is a hallmark of multiple sclerosis (MS) and can be assessed using the kappa free light chain (?-FLC) index. Although widely…

Date: 2026-05-29

Percutaneous nephrostomy as a marker of clinical vulnerability in non-metastatic muscle-invasive bladder cancer: prognostic and infectious implications

Abstract: Percutaneous nephrostomy (PCN) is frequently employed to relieve malignant ureteral obstruction in patients with muscle-invasive bladder cancer (MIBC), yet its…

Date: 2026-05-29

Development and validation of an interpretable stacking-based risk model for breast cancer- related lymphoedema: a cross-sectional study

Abstract: Breast Cancer-Related Lymphedema (BCRL) is one of the common complications after breast cancer treatment. It is characterized by irreversibility and high disability.…

Date: 2026-05-29

Text-guided few-shot liver and tumor segmentation

Abstract: High-precision liver and tumor segmentation is a cornerstone of digital oncology, yet its clinical deployment remains constrained by two persistent challenges: the…

Date: 2026-05-29

High-dimensional immune profiling of peripheral blood identifies immune correlates of anti-PD-1/PD-L1 resistance in oncogenic driver mutation-positive NSCLC

Abstract: Non-small cell lung cancer (NSCLC) patients with oncogenic driver mutations such as EGFR , ALK or ROS1 (mutant-type [MT]) exhibit poor responses to PD-1/PD-L1 immune…

Date: 2026-05-29