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One hotspot RB1 mutation disrupt RB1 function founded in a Chinese patient

Abstract: Retinoblastoma is divided into two clinical types, sporadic and heritable, and is the most common primary intraocular malignancy in infancy and childhood. It was the…

Date: 2026-05-26

Longitudinal trajectories of total, cognitive-affective, and somatic depressive symptoms in relation to hip fracture risk: evidence from the HRS and ELSA cohorts

Abstract: Prior research has established a link between depressive symptoms and the incidence of hip fractures, with most studies relying on a single assessment and failing to…

Date: 2026-05-26

Impact of evidence-based nursing intervention based on Watson’s theory on rehabilitation compliance in elderly patients after intertrochanteric femur fracture surgery

Abstract: The study aimed to unveil the impact of evidence-based nursing (EBN) based on Watson’s theory on rehabilitation compliance in elderly patients with intertrochanteric…

Date: 2026-05-26

Identification of a novel PANoptosis-associated prognostic signature and immune landscape analysis in neuroblastoma with experimental validation

Abstract: Neuroblastoma (NB) is the most common extracranial pediatric solid tumor, and the prognosis of high-risk patients remains poor, while early diagnosis is still…

Date: 2026-05-26

Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages

Abstract: The pathogenesis of ulcerative colitis (UC) remains incompletely understood, and effective therapeutic targets are still lacking in clinical practice. Macrophage…

Date: 2026-05-26

Development and validation of a machine learning model for predicting adverse prognosis in Wallerian degeneration patients based on clinical and imaging data

Abstract: Wallerian degeneration (WD) is a neurodegenerative change that often leads to irreversible neurological dysfunction in the central nervous system, resulting in poor…

Date: 2026-05-26

Clinical characteristics and outcomes of anti-NMDA receptor-dominant autoimmune encephalitis

Abstract: Autoimmune encephalitis (AE) is a multifaceted neuroinflammatory condition characterized by a diverse array of neuropsychiatric symptoms and varying degrees of…

Date: 2026-05-26

Perampanel use in pediatric autoimmune encephalitis-related seizures and epilepsy: a retrospective case series

Abstract: There is limited data regarding the use of antiseizure medications (ASMs) for autoimmune encephalitis (AE)-related seizures and epilepsy, particularly in pediatric…

Date: 2026-05-26

Zapnometinib treatment and influenza A virus infection modulate the HLA class I ligandome in human lung adenocarcinoma cells

Abstract: Influenza viruses continue to pose a global health threat, and available antiviral therapies are limited by resistance and reduced efficacy. Host-directed drugs such as…

Date: 2026-05-26

Porcine Parvovirus virus-like particle vaccine induces long-term humoral immunity by recruiting T follicular helper and germinal center B cell responses

Abstract: Porcine parvovirus (PPV) is a major pathogen causing reproductive disorders in sows and remains widely prevalent worldwide. In recent years, PPV has undergone rapid…

Date: 2026-05-26