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Age-related changes in central corneal thickness and their association with ocular biometric parameters in children

Abstract: To investigate age-related changes in central corneal thickness (CCT) and its relationship with ocular biometric parameters in children. This retrospective study…

Date: 2026-05-22

Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB

Abstract: Intervertebral disc degeneration (IDD) is increasingly viewed as an immune-perturbed and metabolically stressed niche rather than a purely mechanical or aging-related…

Date: 2026-05-22

Laboratory biomarkers and radiographic osteolysis after total knee arthroplasty: a retrospective pilot study

Abstract: This study aimed to identify early risk factors for periprosthetic osteolysis after total knee arthroplasty (TKA) and establish clinically useful predictive biomarkers.…

Date: 2026-05-22

GPX7 marks fibroblast-associated stromal–innate immune crosstalk in ulcerative colitis

Abstract: Ulcerative colitis is sustained by stromal remodeling and innate immune activation. Whether serine-glycine-one-carbon metabolism contributes to fibroblast–macrophage…

Date: 2026-05-22

Risk factors for early neurological deterioration in patients with acute ischaemic stroke and assessment of short-term prognosis

Abstract: To identify independent risk factors for early neurological deterioration (END) in patients with acute ischaemic stroke (AIS) and evaluate its impact on short-term…

Date: 2026-05-22

Magnetic resonance imaging and clinical prediction of intracranial atherosclerotic large vessel occlusion in acute ischemic stroke treated with endovascular thrombectomy

Abstract: Intracranial atherosclerosis-related large-vessel occlusion (ICAS-LVO) poses specific challenges during endovascular thrombectomy, and its early identification is…

Date: 2026-05-22

Endovascular thrombectomy in patients with acute ischemic stroke and prestroke mRS 3: a multicenter IPTW analysis focused on functional preservation

Abstract: Evidence for reperfusion therapy in patients with acute ischemic stroke and prestroke disability remains limited because individuals with prestroke modified Rankin Scale…

Date: 2026-05-22

A novel homozygous ARFGEF2 splice-site variant causing periventricular nodular heterotopia with microcephaly

Abstract: The ARFGEF2 gene encodes the brefeldin A (BFA)-inhibited GEF2 protein (BIG2), which is distributed in the trans-Golgi network and plays a crucial role in neuronal…

Date: 2026-05-22

Real-world study of efgartigimod in AChR antibody-positive generalized myasthenia gravis: thymus status, multi-domain symptom improvement and steroid-sparing effect

Abstract: Efgartigimod has been approved for the treatment of gMG. However, real-world evidence regarding its efficacy across various functional domains in patients with differing…

Date: 2026-05-22

?-Galactosylceramide-expanded virtual memory CD8 + T cells confer protection against a broad range of pathogens

Abstract: ?-Galactosylceramide (?-GalCer) treatment of animals is a well-established model to investigate the beneficial roles of invariant natural killer T (iNKT) cells in…

Date: 2026-05-22