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Management of multiple common bile duct stones via laparoscopic transcholedochal exploration: an observational study

Abstract: The study is an attempt to assess the feasibility of laparoscopic common bile duct exploration (LCBDE) in patients with multiple common bile duct (CBD) stones. A…

Date: 2026-05-21

Preoperative risk stratification for pathological upgrading in colorectal polyps using explainable machine learning: implications for screening optimization and resource allocation

Abstract: Pathological upgrading in colorectal polyps, which occurs when resection specimens have a higher histological grade than preoperative biopsies, can lead to an…

Date: 2026-05-21

Insufficient mycophenolate mofetil maintenance dosage increases the relapse risk in neuromyelitis optica spectrum disorders

Abstract: The utilization of biologic agents for neuromyelitis optica spectrum disorders (NMOSD) is constrained by high cost and limited accessibility in China. While clinical…

Date: 2026-05-21

In vitro generation of ROR?t + regulatory T cells reveals enhanced immunosuppressive function and OXPHOS-dependent metabolism

Abstract: ROR?t + regulatory T cells (Treg) play a crucial role in immune regulation, particularly in the gut. However, most current knowledge about this subset derives from in…

Date: 2026-05-21

Changes in dietary habits following a colon cancer diagnosis: insights from the prospective ECHO (Eating habits CHanges in Oncologic patients) STUDY 2.0

Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. Nevertheless, it is estimated that more than 5.7…

Date: 2026-05-21

Integrative multi-omics analysis identifies SNRPE as a key driver gene in uterine corpus endometrial carcinoma: promoting tumor progression, and mediating immune evasion

Abstract: Uterine corpus endometrial carcinoma (UCEC) has significant inherent resistance to immunotherapy. The tumor microenvironment (TME) in UCEC is characterized by limited…

Date: 2026-05-21

Early toxicity prediction using longitudinal cone-beam CT delta-radiomics in HPV-positive oropharyngeal cancer

Abstract: Long-term survival in human papillomavirus–positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has shifted clinical focus toward minimizing treatment-related…

Date: 2026-05-21

A phase 1 trial of HPV16 E7 T-cell receptor-engineered T cells in patients with relapsed/refractory HPV16-positive cancers (KITE-439 trial)

Abstract: Patients with relapsed/refractory (r/r) HPV-associated epithelial cancers have a poor prognosis. Engineered T cells expressing a T cell receptor (TCR) specific for HPV16…

Date: 2026-05-21

Circulating immune cell profiling in advanced cervical and endometrial cancer patients treated with PD-1 blockade, radiotherapy, and immune modulation in the PRIMMO trial

Abstract: Immune checkpoint blockade (ICB) has revolutionized cancer treatment, including gynecological cancers, yet durable responses are observed only in subsets of patients. To…

Date: 2026-05-21

The instructional modality used for contextual vertical integration of anatomy influences cognitive load and performance during an operative interpretation task in undergraduate gynaecology students: evidence from a multi-centre cluster-randomised controlled trial

Abstract: Operative interpretation is central to the educational value of theatre placements, yet students often struggle to apply preclinical anatomy to the operative setting.…

Date: 2026-05-21