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CD160 mediated NK cell activation shapes host defense against acute Trypanosoma cruzi infection in the skin

Abstract: Trypanosoma cruzi , the causative agent of Chagas disease, enters the host through the skin. While natural killer (NK) cell antimicrobial activity against T. cruzi…

Date: 2026-09-22

Reduced Nectin-4 expression in lymph node metastases of penile squamous cell carcinoma: a paired primary–metastatic analysis

Abstract: To evaluate Nectin-4 expression in primary and matched metastatic penile squamous cell carcinoma (PSCC) lesions and to assess its associations with clinicopathological…

Date: 2026-09-22

Assessing the impact of phosphodiesterase 5 inhibitors on survival in men after treatment for rectal cancer

Abstract: Phosphodiesterase type 5 inhibitors (PDE5Is) facilitate the attainment and maintenance of erections during sexual stimulation. Because erectile dysfunction is common…

Date: 2026-09-22

Real world genomic profiling in non-small cell lung cancer reveals regional variations with clinical implications

Abstract: Routine targeted genomic profiling in non-small cell lung cancer (NSCLC) is primarily used to identify actionable alterations but may provide more information for…

Date: 2026-09-22

Metaplastic breast carcinoma versus triple-negative breast cancer: distinct metastatic patterns and inferior overall survival in a matched retrospective cohort study

Abstract: Metaplastic breast carcinoma (MBC) is an uncommon invasive breast cancer subtype with marked morphological diversity. Many MBCs are managed within the triple-negative…

Date: 2026-09-22

A palmitoylation-related signature predicts prognosis and immune microenvironment features in diffuse large B-cell lymphoma

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma and remains highly heterogeneous in prognosis. Palmitoylation, an important…

Date: 2026-09-22

Baseline indices of cardiorespiratory fitness for predicting acute mountain sickness: an interpretable four-task ensemble model

Abstract: Acute mountain sickness (AMS) poses formidable challenges for individuals venturing into high-altitude (HA) environments. Early and precise prediction of AMS is crucial…

Date: 2026-09-22

Barriers to social participation among patients with hemophilia: a qualitative study using social-ecological systems theory

Abstract: Social participation greatly determines health-related quality of life, while people with hemophilia face severe social engagement restrictions. Current studies only…

Date: 2026-09-21

Single-cell virtual knockout network perturbation prioritizes candidate regulators of beta-cell functional failure in type 2 diabetes

Abstract: Progressive pancreatic beta-cell dysfunction is a central feature of type 2 diabetes (T2D), but disease-associated transcriptional changes alone cannot distinguish…

Date: 2026-09-21

The nomogram prediction model for primary aldosteronism: the combination of serum and urine electrolytes and serum uric acid

Abstract: To construct and preliminarily validate a novel nomogram for primary aldosteronism (PA) risk estimation, with the goal of providing a potential reference tool for PA…

Date: 2026-09-21