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Excessive Internet use and depressive symptom levels in adolescents with depressive disorders: chain mediation of social anxiety and sleep quality

Abstract: Adolescents with depressive disorders are at elevated risk for adverse mental health outcomes, and excessive Internet use has been increasingly linked to greater symptom…

Date: 2026-05-04

Retrospective analysis of clinical efficacy and safety of fluorometholone combined with azelastine eye drops for seasonal allergic conjunctivitis

Abstract: Seasonal allergic conjunctivitis (SAC) is a common ocular allergic disease, predominantly affecting children and young adults, with no significant gender predominance.…

Date: 2026-05-04

A combined model of BCVA, TRAb, and NLR predicts response to intravenous methylprednisolone in dysthyroid optic neuropathy

Abstract: High-dose intravenous methylprednisolone (HD-IVMP) is the first-line treatment for dysthyroid optic neuropathy (DON). However, a significant proportion of patients…

Date: 2026-05-04

Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study

Abstract: Sleep disruption(SD) has been shown to amplify inflammatory signaling and promote pain hypersensitivity, but how inflammation interacts with brain functional alterations…

Date: 2026-05-04

NPHR, FPR, and PLT as predictors of ulcerative colitis severity: a single-center retrospective study in China

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and precise evaluation of disease activity is essential for effective management. This study aimed to…

Date: 2026-05-04

Digital health needs for long-term continuity care in older adult patients: a cross-sectional study under the “internet +” model

Abstract: The “Internet+” initiative offers new possibilities for addressing the complex health needs of aging populations. This cross-sectional study aims to investigate the…

Date: 2026-05-04

Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke

Abstract: Early neurological deterioration (END) in patients with acute ischemic stroke (AIS) leads to a poor prognosis. Previous studies suggest a high risk of END associated…

Date: 2026-05-04

Association of uric acid levels with the risk of severe CED in LVO-AIS patients after mechanical thrombectomy

Abstract: Cerebral edema (CED) significantly exacerbates mortality in patients with acute ischemic stroke (AIS) and can offset the benefits of endovascular therapy. Uric acid (UA)…

Date: 2026-05-04

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry

Abstract: Intravenous thrombolytic (IVT) and mechanical thrombectomy (MT) therapies are the current standard of care for large vessel occlusion (LVO) stroke. Multiple studies…

Date: 2026-05-04

Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization

Abstract: Schnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic…

Date: 2026-05-04