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Mind the delay: duration of untreated psychosis is associated with short-term outcomes in first-episode schizophrenia

Abstract: Schizophrenia is a severe mental disorder associated with substantial disability. Although a growing body of evidence suggests that the duration of untreated psychosis…

Date: 2026-04-29

Leukocyte concentrations of inpatients with anorexia nervosa

Abstract: The leukocyte or white blood cell (WBC) count is a crucial clinical risk marker for anorexia nervosa (AN). Leukocytes can be further classified as granulocytes (e.g.,…

Date: 2026-04-29

Development of cognitive remediation interventions for people living with HIV in South Africa: participant experiences of adapted CogSMART and BrainHQ © programs

Abstract: Previous studies suggest that cognitive remediation training (CRT) programs can help address neurocognitive impairment (NCI) and associated functional challenges in…

Date: 2026-04-29

Single cell transcriptomic analysis reveals pathogenic cell heterogeneity and candidate inflammatory-associated markers in STZ-induced diabetic mouse retina

Abstract: Diabetic retinopathy (DR) is driven by chronic hyperglycemia and involves coordinated vascular, inflammatory, and neuroglial dysfunction. Müller glia are central to…

Date: 2026-04-29

Five-year systemic complications in diabetic retinopathy with integrated optical coherence tomography angiography and glycated hemoglobin

Abstract: This study aimed to develop and validate a multimodal prediction model integrating optical coherence tomography angiography (OCTA) and glycated hemoglobin (HbA1c) for…

Date: 2026-04-29

Ocular manifestations of vitamin A deficiency in gastrointestinal and hepatobiliary disease

Abstract: To characterize clinical features, risk factors, and outcomes of vitamin A deficiency (VAD) among patients with gastrointestinal (GI) and/or hepatobiliary comorbidities.…

Date: 2026-04-29

Distribution of lower limb muscles may be associated with the progression of knee osteoarthritis and sarcopenia: a cross-sectional study

Abstract: This study aimed to delineate and segment the distribution of lower limb muscles based on full-length anteroposterior digital radiography (DR) of patients with varus…

Date: 2026-04-29

From in silico to in vitro : discovery and validation of peptide modulators of IL-6/IL-6R signaling in rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease in which dysregulated interleukin-6 (IL-6) signaling through the IL-6 receptor (IL-6R) plays a central…

Date: 2026-04-29

Metabolic syndrome and risk of incident chronic pancreatitis: a prospective cohort study

Abstract: The association between metabolic syndrome (MetS) and chronic pancreatitis (CP) remains unclear. This study aimed to examine whether MetS is independently associated…

Date: 2026-04-29

Role of enteral nutrition in the clinical care, management, and quality of life of patients with inflammatory bowel disease

Abstract: Enteral nutrition (EN) is essential for Inflammatory Bowel Disease treatment. This applies mainly to Crohn’s disease (CD) and ulcerative colitis (UC) patients. The study…

Date: 2026-04-29