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Current status of 5-aminosalicylic acid in Crohn’s disease treatment: a nationwide survey and analysis of perspectives and practice patterns among inflammatory bowel disease physicians

Abstract: To investigate the perspectives and clinical practice patterns of inflammatory bowel disease (IBD) physicians regarding the use of 5-aminosalicylic acid (5-ASA) in…

Date: 2026-04-27

The impact of psychosocial factors on secondary hyperparathyroidism and vitamin D deficiency in adults with congenital heart disease—the CHD-HYPER study

Abstract: Secondary hyperparathyroidism (sHPT) and vitamin D deficiency are common comorbidities in adults with congenital heart disease (ACHD), but the relationship with…

Date: 2026-04-27

Neuro-immune-epithelial pathways involving substance P may contribute to mucosal pathology in gastro-oesophageal reflux disease

Abstract: Substance P (SP) is contained in nerve fibres innervating the oesophageal mucosa and is released into the mucosa during oesophageal acid perfusion. However, the…

Date: 2026-04-27

Real-world experience with efgartigimod in generalized myasthenia gravis: a single-center retrospective study in China

Abstract: This study aimed to evaluate the real-world efficacy, safety, and application patterns of efgartigimod in Chinese patients with generalized myasthenia gravis (gMG), with…

Date: 2026-04-27

N-terminal pyroglutamylation of an HLA-A24-restricted immunodominant epitope enhances SARS-CoV-2-specific T-cell responses

Abstract: T-cell responses play a critical role in the control of SARS-CoV-2 infections. Here, we examined the T-cell response to a conserved, immunodominant…

Date: 2026-04-27

An interpretable machine learning model for predicting central lymph node metastasis in cN0 T1–T2 papillary thyroid carcinoma: a retrospective study

Abstract: This study aimed to develop and validate an interpretable machine learning model for preoperative prediction of central lymph node metastasis (CLNM) in patients with…

Date: 2026-04-27

Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric cancer risk, chemotherapy efficacy and prognosis

Abstract: To analyze the functions of NDRG family genes in gastric cancer (GC) utilizing bioinformatics. Furthermore, the association between the methylation of NDRG4 gene in…

Date: 2026-04-27

Clinicopathologic correlates of Ewing (FET::ETS-rearranged) sarcoma and non-Ewing undifferentiated small round cell sarcomas across skeletal and extraskeletal sites

Abstract: FET::ETS-rearranged Ewing sarcoma (ES) and non-Ewing undifferentiated small round-cell sarcomas (SRCSs) comprise a morphologically overlapping yet molecularly diverse…

Date: 2026-04-27

Mosaic DICER1 RNase IIIb hotspot mutation with multiple tumors: case report and literature review

Abstract: We present a case of a 6-month-old boy who was diagnosed with Peutz–Jeghers polyps, intestine fusiform mesenchymal tumor, Wilms tumor, and Ir type pleuropulmonary…

Date: 2026-04-27

Radiation-induced xerostomia and oncologic outcomes in nasopharyngeal carcinoma treated with comprehensive salivary gland-sparing helical tomotherapy: a prospective study of 266 patients

Abstract: To evaluate whether comprehensive salivary gland–sparing helical tomotherapy (HT) can reduce radiation-induced xerostomia without compromising locoregional control or…

Date: 2026-04-27