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Biomarker-based clustering identifies distinct pulmonary function trajectories in early systemic sclerosis

Abstract: Systemic sclerosis (SSc) is a heterogeneous autoimmune disease in which interstitial lung disease (ILD) is a major determinant of mortality. Given that certain…

Date: 2026-04-20

Epigenetic downregulation of MAPKAPK2 exacerbates oxidative stress-induced damage in vitiligo melanocyte cell line model

Abstract: Vitiligo is an acquired depigmentation disorder caused by melanocyte dysfunction or loss. Oxidative stress is widely considered a key driver to its pathogenesis.…

Date: 2026-04-20

Long-term follow-up results of percutaneous closure of atrial septal defect with a novel biodegradable poly-L-lactic acid device in pediatrics: data from a prospective, single-center trial

Abstract: The poly-L-lactic acid (PLLA) occluder is a novel, fully biodegradable device designed for percutaneous atrial septal defect (ASD) closure. First-in-human studies have…

Date: 2026-04-20

Clinical manifestations in children with parechovirus A and respiratory tract infection

Abstract: The role of parechovirus A (PeV-A) in respiratory tract infections (RTI) in children remains unclear. We used clinical and virological data from two observational…

Date: 2026-04-20

Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes

Abstract: The sharp increase in prevalence of atopic disease suggests a role for environmental factors, such as the microbiome. Here, we study the impact of immunoglobulin A (IgA)…

Date: 2026-04-20

Macrolide-resistant Mycoplasma pneumoniae in children: clinical features, treatment response, and outcomes in a retrospective cohort from China

Abstract: Macrolide-resistant Mycoplasma pneumoniae (MRMP) has reached extremely high prevalence among children in Asia. However, genotype -phenotype correlations and their impact…

Date: 2026-04-20

Clinical changes in symptomatic cervical ectopy following vaginal hyaluronic acid therapy

Abstract: Cervical ectopy is a common physiological condition in women of reproductive age and may be associated with symptoms such as vaginal discharge, postcoital bleeding,…

Date: 2026-04-20

Molecular mechanism of propofol in reducing kidney injury induced by autologous orthotopic liver transplantation

Abstract: This study explores the mechanism of propofol in autologous orthotopic liver transplantation (AOLT)-insulted kidney injury. A rat model of OALT-induced kidney injury was…

Date: 2026-04-20

Mitochondrial dysfunction in EEG: high-beta specific metabolic/oxidative coupling with lactate in mania-predominant polarity

Abstract: Psychiatric diseases are progressively recognized as disruptions in brain dynamics that can be measured using electrophysiological and metabolic indicators. Conventional…

Date: 2026-04-20

Reversible cupping and persistent vessel narrowing after glaucoma surgery in childhood glaucoma: a quantitative fundus photograph study

Abstract: To investigate postoperative changes in peripapillary retinal vessel caliber and optic disc structure in childhood glaucoma. Prospective, comparative cohort study with a…

Date: 2026-04-20